Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28409269 | 0.71 | ALDH1A1 (0.42) | ALDH1A1CYP1A2TSHRKDM4EHSD17B10 | |
| SCHEMBL13969445 | 0.71 | ALDH1A1 (0.42) | ALDH1A1TSHRKDM4EHSD17B10ALOX15 | |
| SCHEMBL28923743 | 0.71 | ALDH1A1 (0.42) | ALDH1A1CYP1A2TSHRKDM4EHSD17B10 | |
| SCHEMBL6316661 | 0.71 | ALDH1A1 (0.42) | ALDH1A1CYP1A2TSHRKDM4EHSD17B10 | |
| SCHEMBL6896627 | 0.69 | ALDH1A1 (0.35) | ALDH1A1CYP1A2KDM4EHSD17B10ALOX15 | |
| SCHEMBL19336790 | 0.69 | TSHR (0.33) | ALDH1A1CYP1A2TSHRKDM4EHSD17B10 | |
| SCHEMBL27669843 | 0.66 | — | — | |
| SCHEMBL6324046 | 0.65 | PPM1B (0.40) | ALDH1A1CYP1A2TSHRKDM4EHSD17B10 | |
| SCHEMBL15447094 | 0.65 | GAA (0.38) | ALDH1A1TSHRKDM4EHSD17B10ALOX15 | |
| SCHEMBL19324110 | 0.63 | PPM1B (0.44) | ALDH1A1CYP1A2TSHRKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109983022-B | Chroman, isochroman and dihydroisobenzofuran derivatives as mGluR2 negative allosteric modulators, compositions and uses thereof | 默沙东公司 | 2022-06-07 | — | — | CN | disclosed |
| CN-104039956-A | Method of treatment | GLAXOSMITHKLINE IP NO 2 LTD | 2014-09-10 | — | — | CN | disclosed |
| CN-103608346-A | Naphthyridine derivatives as inhibitors of hypoxia inducible factor (HIF) hydroxylase | FIBROGEN INC | 2014-02-26 | — | — | CN | disclosed |
| EP-2670750-A1 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE | Fibrogen, Inc. (US) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012106472-A1 | NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE | FIBROGEN, INC. (US) | 2012-08-09 | — | — | WO | disclosed |
| WO-2004101573-A9 | SYNTHESIS OF SUBSTITUTED HETEROCYCLIC COMPOUNDS | CENTRE NAT RECH SCIENT (FR) | 2005-01-06 | — | — | WO | disclosed |