Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.57 |
| ▸ | HTR3B | O95264 | 1/20 | 0.57 |
| ▸ | HTR1D | P28221 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | HTR3A | P46098 | 1/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729853 | 0.85 | NOTUM (0.58) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL21542324 | 0.81 | NOTUM (0.50) | ALDH1A1NOTUMHRH3KDM4E | |
| SCHEMBL28226906 | 0.81 | ALDH1A1 (0.77) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL1704801 | 0.80 | ALDH1A1 (0.62) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL30388609 | 0.80 | NOTUM (0.56) | ALDH1A1NOTUMKDM4E | |
| Bromide SCHEMBL9310896 | 0.79 | ALDH1A1 (0.60) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL3712914 | 0.79 | ALDH1A1 (0.60) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL17754046 | 0.78 | ALDH1A1 (0.59) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL12706910 | 0.77 | ALDH1A1 (0.72) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D | |
| SCHEMBL30410508 | 0.77 | NOTUM (0.58) | ALDH1A1SIGMAR1HTR3EHTR3BHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | claimed |
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |