Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 16/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6227674 | 0.87 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL6228022 | 0.79 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL6227157 | 0.78 | SIGMAR1 (0.48) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL6234381 | 0.77 | PDE4A (0.42) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL6230195 | 0.77 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL6232717 | 0.77 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6232676 | 0.77 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL6232071 | 0.76 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL6231023 | 0.75 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL6229121 | 0.75 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933366-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2005-04-06 | — | — | EP | disclosed |
| US-6235739-B1 | ANTIINFLAMMATORY AGENTS; ANTIHISTAMINES; SKIN DISORDERS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0933366-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-08-04 | — | — | EP | disclosed |