Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 14/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6187458 | 0.90 | MCHR1 (0.59) | MCHR1KCNH2TSHRKMT2AHSD17B10 | |
| SCHEMBL6188092 | 0.85 | MCHR1 (0.60) | MCHR1KCNH2ALDH1A1TSHRLMNA | |
| SCHEMBL6188058 | 0.83 | MCHR1 (0.80) | MCHR1KCNH2ALDH1A1TSHRLMNA | |
| SCHEMBL6187685 | 0.81 | MCHR1 (0.81) | MCHR1KCNH2ALDH1A1TSHR | |
| SCHEMBL6188162 | 0.79 | MCHR1 (0.80) | MCHR1KCNH2 | |
| SCHEMBL6232398 | 0.78 | MCHR1 (0.66) | MCHR1KCNH2TSHRMEN1KMT2A | |
| SCHEMBL6187797 | 0.77 | MCHR1 (0.73) | MCHR1KCNH2ALDH1A1LMNAMEN1 | |
| SCHEMBL6186119 | 0.77 | LMNA (0.49) | MCHR1KCNH2ALDH1A1TSHRLMNA | |
| SCHEMBL6307274 | 0.77 | MCHR1 (0.75) | MCHR1KCNH2ALDH1A1TSHRMAOB | |
| SCHEMBL6186090 | 0.77 | MCHR1 (0.76) | MCHR1KCNH2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534703-A2 | ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR | ABBOTT LABORATORIES (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2003106452-A2 | ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-12-24 | — | — | WO | disclosed |