Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11692509 | 0.83 | POLB (0.60) | POLBALDH1A1SSTR4KDM4EHPGD | |
| SCHEMBL13626300 | 0.81 | POLB (0.61) | POLBALDH1A1SSTR4KDM4EHPGD | |
| SCHEMBL8351047 | 0.79 | POLB (0.46) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL6233265 | 0.79 | POLB (0.52) | POLBALDH1A1SSTR4KDM4EHPGD | |
| SCHEMBL20738594 | 0.77 | POLB (0.61) | POLBALDH1A1SSTR4KDM4EHPGD | |
| SCHEMBL8354032 | 0.75 | POLB (0.48) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8781558 | 0.75 | ALDH1A1 (0.39) | POLBALDH1A1SSTR4KDM4EHPGD | |
| SCHEMBL8781615 | 0.74 | POLB (0.39) | POLBALDH1A1SSTR4KDM4EHPGD | |
| SCHEMBL21162019 | 0.74 | POLB (0.47) | POLBALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL30299580 | 0.74 | CYP2C19 (0.58) | POLBALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990641-B1 | Process for the synthesis of alpha-substituted ring systems | BAYER CHEMICALS AG (DE) | 2004-03-17 | — | — | EP | disclosed |
| US-6235925-B1 | RING CLOSURE METHATHESIS AND NOBLE METAL CATALYSTS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-05-22 | — | — | US | disclosed |
| EP-0990641-A1 | Process for the synthesis of alpha-substituted ring systems | Bayer Aktiengesellschaft (DE) | 2000-04-05 | — | — | EP | disclosed |