⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233582 | 1.00 | — | — | |
| SCHEMBL6233576 | 1.00 | — | — | |
| SCHEMBL9749501 | 0.91 | — | — | |
| SCHEMBL9749503 | 0.91 | — | — | |
| SCHEMBL9749508 | 0.91 | — | — | |
| SCHEMBL13806071 | 0.90 | — | — | |
| SCHEMBL2487430 | 0.90 | — | — | |
| SCHEMBL2638948 | 0.90 | — | — | |
| Ammonia Solution, Strong SCHEMBL5821531 | 0.90 | — | — | |
| SCHEMBL2638946 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668504-A | Use of substituted propenoates to prevent nephrotoxicity of certain antibiotics | MERCK & CO., INC. (US) | 1987-05-26 | — | — | US | claimed |
| EP-1161947-B1 | Oral antibacterial compositions and method for the improvement of gastrointestinal absorption of penem or carbapenem antibiotics | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-06-08 | — | — | EP | disclosed |
| EP-0497353-B1 | Use of cilastatin, glutathione or N-acetyl-L-cysteine for the preparation of a medicament for the improvement of gastrointestinal absorption of penem or carbapenem antibiotics | SUNTORY LTD (JP) | 2002-05-08 | — | — | EP | disclosed |
| EP-1161947-A2 | Oral antibacterial compositions and method for the improvement of gastrointestinal absorption of penem or carbapenem antibiotics | SUNTORY LIMITED (JP) | 2001-12-12 | — | — | EP | disclosed |
| US-5637612-A | MIXTURE WITH DIPEPTIDASE INHIBITOR | SUNTORY LIMITED (JP) | 1997-06-10 | — | — | US | disclosed |
| US-5354748-A | Cilastin as an inhibitor of the dipeptidase-like enzyme localized on/in epithelial cells of the small intestine | SUNTORY LIMITED (JP) | 1994-10-11 | — | — | US | disclosed |
| US-5147868-A | For selectively inhibiting the metabolism of dipeptidase; useful in mixtures with bactericides | MERCK & CO., INC. (US) | 1992-09-15 | — | — | US | disclosed |
| US-5071843-A | Thienamycin antibiotics with delayed metabolism | MERCK & CO., INC. (US) | 1991-12-10 | — | — | US | disclosed |
| EP-0161546-B1 | COMBINATION OF 2-SUBSTITUTED CARBAPENEMS WITH DIPEPTIDASE INHIBITORS | MERCK & CO. INC. (US) | 1989-12-13 | — | — | EP | disclosed |
| US-4880793-A | BACTERICIDES, UNSATURATED CARBOXYLIC ACID, AMIDES | MERCK & CO., INC. (US) | 1989-11-14 | — | — | US | disclosed |
| US-4616038-A | BACTERICIDES | MERCK & CO., INC. (US) | 1986-10-07 | — | — | US | disclosed |
| EP-0161546-A1 | Combination of 2-substituted carbapenems with dipeptidase inhibitors | MERCK & CO. INC. (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4539208-A | Combination of thienamycin-type antibiotics with dipeptidase inhibitors | MERCK & CO., INC. (US) | 1985-09-03 | — | — | US | disclosed |
| EP-0028778-B1 | ANTIBACTERIAL COMPOSITIONS COMPRISING A BETA-LACTAM-TYPE COMPOUND AND A 3-SUBSTITUTED PROPENOATE | MERCK & CO. INC. (US) | 1985-01-16 | — | — | EP | disclosed |
| EP-0010573-B1 | NOVEL Z-2-ACYLAMINO-3-MONOSUBSTITUTED PROPENIC ACIDS AND THEIR ESTERS AND SALTS, AND PROCESSES FOR PREPARING THEM | MERCK & CO. INC. (US) | 1983-10-19 | — | — | EP | disclosed |
| EP-0072014-A1 | Combination of 2-substituted penems with dipeptidase inhibitors | MERCK & CO. INC. (US) | 1983-02-16 | — | — | EP | disclosed |
| EP-0048025-A1 | Antibacterial composition of thienamycin type compound and a dipeptidase inhibitor | MERCK & CO. INC. (US) | 1982-03-24 | — | — | EP | disclosed |
| EP-0028778-A1 | Antibacterial compositions comprising a beta-lactam-type compound and a 3-substituted propenoate | MERCK & CO. INC. (US) | 1981-05-20 | — | — | EP | disclosed |
| EP-0010573-A1 | Novel Z-2-acylamino-3-monosubstituted propenic acids and their esters and salts, and processes for preparing them | MERCK & CO. INC. (US) | 1980-05-14 | — | — | EP | disclosed |
| EP-0007614-A1 | An antibacterial composition of thienamycin-type compound and a dipeptidase inhibitor | MERCK & CO. INC. (US) | 1980-02-06 | — | — | EP | disclosed |