Sugi Predict

Sugi Predict / Compounds / SCHEMBL6233670

SCHEMBL6233670

SCHEMBL6233670

O=c1c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2ccccc2n1CC1CCOC1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 1/20 0.63
▸ HSD17B10 Q99714 1/20 0.63
▸ CYP2C9 P11712 3/20 0.57
▸ NR1I2 O75469 1/20 0.57
▸ FEN1 P39748 3/20 0.39
▸ ERCC5 P28715 1/20 0.39
▸ CNR2 P34972 2/20 0.38
▸ CNR1 P21554 1/20 0.38
▸ MAPT P10636 1/20 0.34
▸ KDM4E B2RXH2 3/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ GAA P10253 2/20 0.34
▸ RXFP1 Q9HBX9 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ RCE1 Q9Y256 1/20 0.33
▸ GSK3B P49841 1/20 0.33
▸ PARG Q86W56 1/20 0.33
▸ ROCK2 O75116 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6238527 0.90 MAPK1 (0.71) MAPK1HSD17B10CYP2C9NR1I2MAPT
SCHEMBL6209089 0.87 HSD17B10 (0.67) MAPK1HSD17B10CYP2C9NR1I2FEN1
SCHEMBL6233481 0.85 MAPK1 (0.64) MAPK1HSD17B10CYP2C9NR1I2KDM4E
SCHEMBL6209924 0.83 CYP2C9 (0.80) MAPK1HSD17B10CYP2C9NR1I2MAPT
SCHEMBL6235665 0.82 HSD17B10 (0.70) MAPK1HSD17B10CYP2C9NR1I2MAPT
SCHEMBL6685735 0.80 MAPK1 (0.57) MAPK1HSD17B10CYP2C9NR1I2CNR2
SCHEMBL1379864 0.80 MAPK1 (0.57) MAPK1HSD17B10CYP2C9NR1I2MAPT
SCHEMBL6739989 0.79 HSD17B10 (0.74) MAPK1HSD17B10CYP2C9NR1I2MAPT
SCHEMBL6211629 0.78 HSD17B10 (0.72) MAPK1HSD17B10CYP2C9NR1I2MAPT
SCHEMBL6238046 0.78 HSD17B10 (0.72) MAPK1HSD17B10CYP2C9NR1I2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401443-A4 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORP (US) 2005-10-26 — — EP claimed
CN-1535151-A Novel anti-infectives ʷ��˿�������ȳ�ķ���޹�˾ 2004-10-06 — — CN claimed
US-20040147739-A1 Novel anti-infectives SMITHKLINE BEECHAM CORPORATION 2004-07-29 — — US claimed
EP-1401443-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2004-03-31 — — EP claimed
WO-2002098424-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2002-12-12 — — WO claimed
EP-1401443-A4 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORP (US) 2005-10-26 — — EP disclosed
US-20040147739-A1 Novel anti-infectives SMITHKLINE BEECHAM CORPORATION 2004-07-29 — — US disclosed
EP-1401443-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2004-03-31 — — EP disclosed
WO-2002098424-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2002-12-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040147739-A1 Novel anti-infectives RPL5, RPL7, RPL35 MAPK1 3699/4885HSD17B10 1428/4885CYP2C9 1218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.