⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768669 | 0.80 | ALDH1A1 (0.42) | — | |
| SCHEMBL19259942 | 0.80 | — | — | |
| SCHEMBL15676022 | 0.79 | ALDH1A1 (0.38) | — | |
| SCHEMBL4314802 | 0.79 | ALDH1A1 (0.38) | — | |
| SCHEMBL15676401 | 0.79 | ALDH1A1 (0.38) | — | |
| SCHEMBL4314807 | 0.79 | ALDH1A1 (0.38) | — | |
| SCHEMBL15676503 | 0.79 | ALDH1A1 (0.38) | — | |
| SCHEMBL4489846 | 0.76 | — | — | |
| SCHEMBL8267529 | 0.76 | — | — | |
| SCHEMBL267683 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1626525-A | Process for the preparation of thiazole derivatives | SYNGENTA CROP PROT INC (CH) | 2005-06-15 | — | — | CN | disclosed |
| EP-1202979-B1 | PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2005-04-27 | — | — | EP | disclosed |
| CN-1169800-C | Process for preparing thiazole derivatives | �����ɷ� | 2004-10-06 | — | — | CN | disclosed |
| US-6710182-B2 | REACTING 5-HYDROXYMETHYLTHIAZOLE-DIAZONIUM SALT WITH HYDROGEN HALIDE OR MINERAL ACID; CHLORINATION, DESALTING, DEHYDROXYLATION | SYNGENTA CROP PROTECTION, INC. | 2004-03-23 | — | — | US | disclosed |
| US-20030191321-A1 | PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES | COPPOLA KEVIN (US) | 2003-10-09 | — | — | US | disclosed |
| US-6566530-B2 | Preparing 2-chloro-5-chloromethylthiazole by reacting 2-hydroxy-5-hydroxymethylthiazole with a chloride anion source in the presence of an acid. | SYNGENTA CROP PROTECTION, INC. | 2003-05-20 | — | — | US | disclosed |
| US-20030055229-A1 | Process for the preparation of thiazole derivatives | COPPOLA KEVIN (US) | 2003-03-20 | — | — | US | disclosed |
| US-6476230-B1 | Process for the preparation of thiazole derivatives | SYNGENTA CROP PROTECTION, INC. | 2002-11-05 | — | — | US | disclosed |
| CN-1368966-A | Process for preparing thiazole derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2002-09-11 | — | — | CN | disclosed |
| EP-1202979-A1 | PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES | Syngenta Participations AG (CH) | 2002-05-08 | — | — | EP | disclosed |
| US-6265553-B1 | INTERMEDIATES FOR INSECTICIDES | SYNGENTA CROP PROTECTION, INC. | 2001-07-24 | — | — | US | disclosed |
| WO-2001010852-A1 | PROCESS FOR THE PREPARATION OF THIAZOLE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2001-02-15 | — | — | WO | disclosed |