Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.67 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | APEX1 | P27695 | 3/20 | 0.51 |
| ▸ | PSMB8 | P28062 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233959 | 1.00 | STAT3 (0.67) | STAT3GSK3AGSK3BINSRIGF1R | |
| SCHEMBL1430728 | 0.81 | STAT3 (1.00) | STAT3INSRIGF1RTDP1APEX1 | |
| SCHEMBL16496688 | 0.81 | STAT3 (1.00) | STAT3INSRIGF1RTDP1APEX1 | |
| SCHEMBL21852264 | 0.79 | MAPT (0.55) | STAT3GSK3AGSK3BINSRIGF1R | |
| SCHEMBL20339281 | 0.79 | MAPT (0.55) | STAT3GSK3AGSK3BINSRIGF1R | |
| SCHEMBL14667431 | 0.79 | STAT3 (0.50) | STAT3KDM4EMAPTAPEX1PSMB8 | |
| SCHEMBL5146767 | 0.78 | STAT3 (0.80) | STAT3TDP1PSMB8L3MBTL1ALDH1A1 | |
| SCHEMBL5146772 | 0.78 | STAT3 (0.80) | STAT3TDP1PSMB8L3MBTL1ALDH1A1 | |
| SCHEMBL21852265 | 0.75 | TDP1 (0.58) | STAT3KDM4ETDP1MAPTAPEX1 | |
| SCHEMBL20339335 | 0.75 | TDP1 (0.58) | STAT3KDM4ETDP1MAPTAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050191612-A1 | Method of screening insulin content enhancer | ASTELLAS PHARMA INC. (JP) | 2005-09-01 | — | — | US | disclosed |
| EP-1538217-A1 | METHOD OF SCREENING INSULIN CONTENT ENHANCER | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2005-06-08 | — | — | EP | disclosed |