Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.80 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.71 |
| ▸ | PSMB8 | P28062 | 7/20 | 0.65 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.62 |
| ▸ | ITGAM | P11215 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.59 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.59 |
| ▸ | PTPN22 | Q9Y2R2 | 2/20 | 0.58 |
| ▸ | CDK2 | P24941 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5146772 | 1.00 | STAT3 (0.80) | STAT3ENPP2PSMB8ITGB2ITGAM | |
| SCHEMBL1430728 | 0.89 | STAT3 (1.00) | STAT3ENPP2PSMB8MEN1KMT2A | |
| SCHEMBL16496688 | 0.89 | STAT3 (1.00) | STAT3ENPP2PSMB8MEN1KMT2A | |
| SCHEMBL17088410 | 0.87 | ITGB2 (0.71) | STAT3ENPP2PSMB8ITGB2ITGAM | |
| SCHEMBL12177763 | 0.87 | ENPP2 (0.69) | STAT3ENPP2PSMB8ITGB2ITGAM | |
| SCHEMBL46552 | 0.86 | PTPN22 (0.75) | STAT3ENPP2PSMB8ITGB2ITGAM | |
| SCHEMBL5144867 | 0.86 | PTPN22 (0.75) | STAT3ENPP2PSMB8ITGB2ITGAM | |
| SCHEMBL684272 | 0.86 | ENPP2 (0.83) | STAT3ENPP2PSMB8ITGB2ITGAM | |
| SCHEMBL16687571 | 0.86 | ENPP2 (0.82) | STAT3ENPP2PSMB8ITGB2ITGAM | |
| SCHEMBL684546 | 0.83 | ENPP2 (1.00) | STAT3ENPP2PSMB8NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718308-A4 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORP (CA) | 2007-07-18 | — | — | EP | disclosed |
| EP-1718308-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PainCeptor Pharma Corp. (CA) | 2006-11-08 | — | — | EP | disclosed |
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-12-22 | — | — | US | disclosed |
| WO-2005076695-A2 | METHODS OF MODULATING NEUROTROPHIN-MEDIATED ACTIVITY | PAINCEPTOR PHARMA CORPORATION (CA) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282840-A1 | Methods of modulating neurotrophin-mediated activity | NGF, BDNF, NTRK2 | STAT3 1399/4885ENPP2 411/4885PSMB8 3663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.