Sugi Predict

Sugi Predict / Compounds / SCHEMBL6234490

SCHEMBL6234490

SCHEMBL6234490

CC(C)CCn1c(=O)c(C2=NS(=O)(=O)c3ccccc3N2)c(O)c2cc(C(=O)O)ccc21

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 1/20 0.64
▸ HSD17B10 Q99714 1/20 0.64
▸ CYP2C9 P11712 3/20 0.58
▸ NR1I2 O75469 1/20 0.58
▸ KDM4E B2RXH2 2/20 0.40
▸ ALDH1A1 P00352 3/20 0.38
▸ HPGD P15428 2/20 0.37
▸ PTGDR2 Q9Y5Y4 1/20 0.35
▸ DPP4 P27487 2/20 0.35
▸ TAAR1 Q96RJ0 1/20 0.35
▸ CHEK1 O14757 1/20 0.35
▸ WEE1 P30291 1/20 0.35
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ LMNA P02545 1/20 0.34
▸ HTT P42858 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27585690 0.92 MAPK1 (0.65) MAPK1HSD17B10CYP2C9NR1I2KDM4E
SCHEMBL6238636 0.91 MAPK1 (0.61) MAPK1HSD17B10CYP2C9NR1I2KDM4E
SCHEMBL6238240 0.91 MAPK1 (0.61) MAPK1HSD17B10CYP2C9NR1I2KDM4E
SCHEMBL6236084 0.90 MAPK1 (0.60) MAPK1HSD17B10CYP2C9NR1I2KDM4E
SCHEMBL6232673 0.90 HSD17B10 (0.64) MAPK1HSD17B10CYP2C9NR1I2KDM4E
SCHEMBL6235652 0.90 MAPK1 (0.68) MAPK1HSD17B10CYP2C9NR1I2KDM4E
SCHEMBL6232411 0.89 MAPK1 (0.67) MAPK1HSD17B10CYP2C9NR1I2KDM4E
SCHEMBL6739082 0.89 MAPK1 (0.67) MAPK1HSD17B10CYP2C9NR1I2ALDH1A1
SCHEMBL6233871 0.88 MAPK1 (0.66) MAPK1HSD17B10CYP2C9NR1I2ALDH1A1
SCHEMBL6231207 0.88 MAPK1 (0.66) MAPK1HSD17B10CYP2C9NR1I2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401443-A4 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORP (US) 2005-10-26 — — EP claimed
CN-1535151-A Novel anti-infectives ʷ��˿�������ȳ�ķ���޹�˾ 2004-10-06 — — CN claimed
US-20040147739-A1 Novel anti-infectives SMITHKLINE BEECHAM CORPORATION 2004-07-29 — — US claimed
EP-1401443-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2004-03-31 — — EP claimed
WO-2002098424-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2002-12-12 — — WO claimed
CN-1535151-A Novel anti-infectives ʷ��˿�������ȳ�ķ���޹�˾ 2004-10-06 — — CN disclosed
US-20040147739-A1 Novel anti-infectives SMITHKLINE BEECHAM CORPORATION 2004-07-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040147739-A1 Novel anti-infectives RPL5, RPL7, RPL35 MAPK1 3699/4885HSD17B10 1428/4885CYP2C9 1218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.