Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 7/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.35 |
| ▸ | CASP1 | P29466 | 7/20 | 0.35 |
| ▸ | CASP7 | P55210 | 7/20 | 0.35 |
| ▸ | USP2 | O75604 | 6/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6233946 | 0.88 | DPP4 (0.50) | RPS6KB2PDGFRBPDGFRALTA4HCYP1A2 | |
| SCHEMBL6236374 | 0.84 | RPS6KB2 (0.54) | RPS6KB2PDGFRBPDGFRACYP1A2CASP1 | |
| SCHEMBL6257438 | 0.81 | USP2 (0.44) | RPS6KB2CYP1A2CASP1CASP7USP2 | |
| SCHEMBL6234678 | 0.79 | DPP4 (0.50) | RPS6KB2PDGFRBPDGFRACYP1A2CASP1 | |
| SCHEMBL6234523 | 0.77 | CYP1A2 (0.42) | RPS6KB2CYP1A2CASP1CASP7USP2 | |
| SCHEMBL6237105 | 0.76 | RPS6KB2 (0.49) | RPS6KB2PDGFRBPDGFRACYP1A2CASP1 | |
| SCHEMBL6233813 | 0.75 | RPS6KB2 (0.43) | RPS6KB2PDGFRBPDGFRACYP1A2CASP1 | |
| SCHEMBL6237798 | 0.74 | RPS6KB2 (0.52) | RPS6KB2PDGFRBPDGFRADHFRSRPK1 | |
| SCHEMBL6240032 | 0.74 | RPS6KB2 (0.42) | RPS6KB2PDGFRBPDGFRACYP1A2CASP1 | |
| SCHEMBL6236517 | 0.73 | CYP2A6 (0.55) | RPS6KB2PDGFRBPDGFRACASP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |