Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL4603082 | 0.87 | — | — | |
| Phosphine SCHEMBL27494537 | 0.87 | — | — | |
| Methyl Alcohol SCHEMBL27569221 | 0.83 | POLB (0.45) | POLBCYP3A4TSHRPIK3CATDP2 | |
| Hydrochloric Acid SCHEMBL8149159 | 0.83 | POLB (0.45) | POLBCYP3A4TSHRPIK3CATDP2 | |
| SCHEMBL11225788 | 0.80 | POLB (0.43) | POLBCYP3A4TDP2NSD2HSP90AA1 | |
| SCHEMBL23854312 | 0.77 | POLB (0.55) | POLBCYP3A4TSHRTDP2NSD2 | |
| SCHEMBL489198 | 0.77 | POLB (0.41) | POLBCYP3A4TDP2NSD2HSP90AA1 | |
| SCHEMBL31673873 | 0.77 | POLB (0.55) | POLBCYP3A4TSHRTDP2NSD2 | |
| Hydrochloric Acid SCHEMBL526310 | 0.77 | POLB (0.48) | POLBCYP3A4TSHRPIK3CAACHE | |
| SCHEMBL3220414 | 0.77 | POLB (0.48) | POLBCYP3A4TSHRPIK3CAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004582-B1 | Pyridazino quinoline compounds | ASTRAZENECA AB (SE) | 2005-05-18 | — | — | EP | disclosed |
| EP-0724583-B1 | PYRIDAZINO QUINOLINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-13 | — | — | EP | disclosed |
| EP-1004582-A2 | Pyridazino quinoline compounds | AstraZeneca UK Limited (GB) | 2000-05-31 | — | — | EP | disclosed |