Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | G6PD | P11413 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | CCR6 | P51684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL27569221 | 0.85 | POLB (0.45) | POLBTDP2NSD2HSP90AA1PAX8 | |
| SCHEMBL11225788 | 0.81 | POLB (0.43) | POLBTDP2NSD2HSP90AA1PAX8 | |
| Ammonia Solution, Strong SCHEMBL4603082 | 0.81 | — | — | |
| Phosphine SCHEMBL27494537 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL8149159 | 0.77 | POLB (0.45) | POLBTDP2NSD2HSP90AA1PAX8 | |
| Hydrazine SCHEMBL6235543 | 0.77 | POLB (0.53) | POLBTDP2NSD2HSP90AA1PAX8 | |
| SCHEMBL20953846 | 0.76 | ACHE (0.32) | — | |
| SCHEMBL17924077 | 0.74 | POLB (0.44) | POLBTDP2NSD2HSP90AA1PAX8 | |
| SCHEMBL573212 | 0.73 | AR (0.47) | POLBKDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL23854312 | 0.71 | POLB (0.55) | POLBTDP2NSD2HSP90AA1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527195-B | 5-aryl nicotinamide LSD1/HDAC double-target inhibitor, preparation method and application thereof | 新乡医学院 | 2022-09-20 | — | — | CN | disclosed |
| EP-3475262-B1 | BICYCLIC IMIDAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF RENAL DISEASE, CARDIOVASCULAR DISEASES AND FIBROTIC DISORDERS | BOEHRINGER INGELHEIM INT (DE) | 2021-03-24 | — | — | EP | disclosed |
| US-10858342-B2 | Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-12-08 | — | — | US | disclosed |
| US-20200109131-A1 | BICYCLIC IMIDAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF RENAL DISEASES, CARDIOVASCULAR DISEASES AND FIBROTIC DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-09 | — | — | US | disclosed |
| CN-105153235-B | Phosphor material | 通用显示公司 | 2019-05-10 | — | — | CN | disclosed |
| EP-3475262-A1 | BICYCLIC IMIDAZOLE DERIVATIES USEFUL FOR THE TREATMENT OF RENAL DISEASE, CARDIOVASCULAR DISEASES AND FIBROTIC DISORDERS | Boehringer Ingelheim International GmbH (DE) | 2019-05-01 | — | — | EP | disclosed |
| CN-108779206-A | The manufacturing method of alkene-aromatic ethenyl compound based copolymer and the manufacturing method for intersecting copolymer | 电化株式会社 | 2018-11-09 | — | — | CN | disclosed |
| WO-2018005177-A1 | BICYCLIC IMIDAZOLE DERIVATIES USEFUL FOR THE TREATMENT OF RENAL DISEASE, CARDIOVASCULAR DISEASES AND FIBROTIC DISORDERS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-01-04 | — | — | WO | disclosed |
| CN-102471291-B | 3-triazolylphenyl-substituted sulfide derivatives for use as acaricides and insecticides | BAYER CROPSCIENCE AG | 2015-04-22 | — | — | CN | disclosed |
| US-8501993-B2 | Processes for the preparation of amides | SYNGENTA LIMITED (GB) | 2013-08-06 | — | — | US | disclosed |
| EP-1620434-A1 | FUSED BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS | Abbott Laboratories (US) | 2006-02-01 | — | — | EP | disclosed |
| US-20040248899-A1 | Fused bicyclic-substituted amines as histamine-3 receptor ligands | ABBVIE INC. | 2004-12-09 | — | — | US | disclosed |
| WO-2004101559-A1 | FUSED BICYCLIC-SUBSTITUTED AMINES AS HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2004-11-25 | — | — | WO | disclosed |
| US-20040224953-A1 | e.g., 4-{2-[2-(2-(R)-Methyl-pyrrolidin-1-yl)-ethyl]-benzothiazol-5-yl}-benzonitrile; useful for treating conditions and disorders related to memory and cognition processes, neurological processes, cardiovascular function, and body weight. | ABBOTT LABORATORIES | 2004-11-11 | — | — | US | disclosed |
| US-20040224952-A1 | Fused bicyclic-substituted amines as histamine-3 receptor ligands | ABBOTT LABORATORIES | 2004-11-11 | — | — | US | disclosed |
| US-20040167364-A1 | Production method of a coupling compound | SUMITOMO CHEMICAL COMPANY, LIMITED | 2004-08-26 | — | — | US | disclosed |
| US-20040161404-A1 | Method for producing coupling compound | SUMITOMO CHEMICAL COMPANY, LIMITED | 2004-08-19 | — | — | US | disclosed |
| EP-1439157-A2 | Method for producing Suzuki coupling compound catalysed by a nickel compound | Sumitomo Chemical Co.,Ltd. (JP) | 2004-07-21 | — | — | EP | disclosed |
| EP-0794942-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-09-17 | — | — | EP | disclosed |
| WO-1996016934-A1 | SUBSTITUTED BIPHENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-06-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248899-A1 | Fused bicyclic-substituted amines as histamine-3 receptor ligands | HRH3, HRH4, HRH1 | POLB 4599/4885TDP2 4787/4885NSD2 3920/4885 |
| US-20040224953-A1 | e.g., 4-{2-[2-(2-(R)-Methyl-pyrrolidin-1-yl)-ethyl]-benzothiazol-5-yl}-benzonitrile; useful for treating conditions and disorders related to memory and cognition processes, neurological processes, cardiovascular function, and body weight. | HRH4, HRH3, HRH2 | POLB 4418/4885TDP2 3218/4885NSD2 2915/4885 |
| US-20040167364-A1 | Production method of a coupling compound | PYM1, BRIX1, CXCR1 | POLB 1043/4885TDP2 3929/4885NSD2 2123/4885 |
| US-20040224952-A1 | Fused bicyclic-substituted amines as histamine-3 receptor ligands | HRH3, HRH4, HRH1 | POLB 4599/4885TDP2 4787/4885NSD2 3920/4885 |
| US-20040161404-A1 | Method for producing coupling compound | PYM1, MALT1, BET1 | POLB 1693/4885TDP2 4037/4885NSD2 1996/4885 |
| US-10858342-B2 | Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases | REN, AGTR1, AGTR2 | POLB 4237/4885TDP2 3079/4885NSD2 3232/4885 |
| US-20200109131-A1 | BICYCLIC IMIDAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF RENAL DISEASES, CARDIOVASCULAR DISEASES AND FIBROTIC DISEASES | REN, AGTR1, AGTR2 | POLB 4237/4885TDP2 3079/4885NSD2 3232/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.