Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667357 | 0.89 | HRH3 (0.43) | HRH3KDM4ETSHRCHRM2HTR1A | |
| SCHEMBL6637302 | 0.86 | KCNH2 (0.44) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL6635619 | 0.84 | CA12 (0.35) | HRH3KDM4ECNR2TSHRMAPK1 | |
| SCHEMBL7140660 | 0.82 | CHRNB2 (0.50) | KDM4ETSHRMAOBCYP1A2CYP2D6 | |
| SCHEMBL6634540 | 0.82 | MAPT (0.50) | HRH3CHRM2HTR1AADRA2ACHRM1 | |
| SCHEMBL6234599 | 0.81 | DRD3 (0.43) | HRH3CHRM2HTR1AADRA2ACHRM1 | |
| SCHEMBL6638680 | 0.80 | KCNH2 (0.45) | HRH3OPRM1DRD3KCNH2BCHE | |
| SCHEMBL6637319 | 0.79 | BCHE (0.35) | HRH3KDM4ETSHRADRA2ASLC6A2 | |
| SCHEMBL1041217 | 0.79 | TSHR (0.54) | HRH3TSHRSLC6A2SLC6A4ADRA1A | |
| SCHEMBL6640076 | 0.79 | KCNH2 (0.47) | OPRM1DRD3KCNH2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165557-B1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORP (US) | 2004-09-29 | — | — | EP | claimed |
| US-6627624-B1 | Agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors, and are therefore useful in the diagnosis and treatment of anxiety, Down Syndrome, | NEUROGEN CORPORATION | 2003-09-30 | — | — | US | claimed |
| EP-0836613-B1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | METABASIS THERAPEUTICS INC (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1165557-B1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6627624-B1 | Agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors, and are therefore useful in the diagnosis and treatment of anxiety, Down Syndrome, | NEUROGEN CORPORATION | 2003-09-30 | — | — | US | disclosed |
| US-5795977-A | Water soluble adenosine kinase inhibitors | METABASIS THERAPEUTICS, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| EP-0836613-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-22 | — | — | EP | disclosed |
| US-5726302-A | SUBSTITUTED 4-AMINO PYRROLO(2,3-D) PYRIMIDINE AND PYRAZOLO(3,4-D) PYRIMIDINE NUCLEOSIDE ANALOGS | GENSIA INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5654302-A | Prodrug esters of phenolic 2-piperidino-1-alkanols | PFIZER INC. (US) | 1997-08-05 | — | — | US | disclosed |
| US-5594007-A | Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols | PFIZER INC. (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1996040707-A1 | WATER-SOLUBLE ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5455250-A | Prodrug esters of phenolic 2-piperidino-1-alkanols | PFIZER INC. (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0584192-A1 | PRODRUG ESTERS OF PHENOLIC 2-PIPERIDINO-1-ALKANOLS | PFIZER INC. (US) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992018502-A1 | PRODRUG ESTERS OF PHENOLIC 2-PIPERIDINO-1-ALKANOLS | PFIZER INC. (US) | 1992-10-29 | — | — | WO | disclosed |