SCHEMBL623582

SCHEMBL623582

O=C(Nc1ncc(Cl)s1)C(SC1CCCC1)c1ccc(S(=O)(=O)C2CC2)cc1

nearest known ligand 0.54

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
GCK P35557 18/20 0.54
KCNH2 Q12809 1/20 0.53
FFAR2 O15552 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2655950 0.78 GCK (0.66) GCKKCNH2FFAR2
SCHEMBL2658893 0.76 GCK (0.60) GCK
SCHEMBL2657739 0.74 GCK (0.58) GCK
SCHEMBL2657952 0.74 GCK (0.71) GCK
SCHEMBL2657285 0.73 GCK (0.75) GCK
SCHEMBL2656181 0.73 GCK (0.66) GCK
SCHEMBL1565893 0.73 FFAR2 (0.47) FFAR2
SCHEMBL13696222 0.73 GCK (0.66) GCKKCNH2
SCHEMBL1565486 0.72 GCK (0.66) GCKKCNH2
SCHEMBL622629 0.71 GCK (0.54) GCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012020357-A1 ACETAMIDE COMPOUNDS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION ADVINUS THERAPEUTICS LTD. (IN) 2012-02-16 WO claimed
WO-2012020357-A1 ACETAMIDE COMPOUNDS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION ADVINUS THERAPEUTICS LTD. (IN) 2012-02-16 WO disclosed