Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8529578 | 0.81 | PDE10A (0.47) | MAPTLMNATRPV1PIM1SLC40A1 | |
| SCHEMBL14053276 | 0.78 | HSP90AA1 (0.49) | MAPTSMN1; SMN2LMNAGAAHTT | |
| SCHEMBL7230237 | 0.78 | MAP4K4 (0.47) | MAPTGAATRPV1PIM1NPC1 | |
| SCHEMBL444703 | 0.77 | ALDH1A1 (0.53) | MAPTTRPV1NPC1CYP1A2CYP2C19 | |
| SCHEMBL28185546 | 0.77 | SCN2A (0.44) | MAPTGAASCN2ANPC1CYP3A4 | |
| SCHEMBL8981842 | 0.77 | ALDH1A1 (0.59) | MAPTLMNASCN2ACYP3A4EIF4E | |
| SCHEMBL16097359 | 0.76 | ERN1 (0.51) | MAPTTRPV1PDE10APDE4DMAPK1 | |
| SCHEMBL8529531 | 0.75 | ALDH1A1 (0.46) | MAPTLMNAGAATRPV1CYP1A2 | |
| SCHEMBL16119989 | 0.75 | ALDH1A1 (0.51) | TRPV1PDE10APDE4DPOLB | |
| SCHEMBL27866903 | 0.75 | DYRK1A (0.56) | MAPTSMN1; SMN2LMNAGAAKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |