Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.36 |
| ▸ | PRKCA | P17252 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PPP5C | P53041 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12164742 | 1.00 | SPHK1 (0.47) | SPHK1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL12164706 | 0.83 | LMNA (0.43) | SPHK1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL12164689 | 0.82 | SPHK1 (0.43) | SPHK1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL12464330 | 0.80 | SPHK1 (0.41) | SPHK1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL17202888 | 0.77 | LMNA (0.39) | SPHK1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL17202889 | 0.77 | LMNA (0.39) | SPHK1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL17224247 | 0.77 | LMNA (0.39) | SPHK1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL2319591 | 0.77 | LMNA (0.39) | SPHK1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL12164707 | 0.77 | SPHK1 (0.43) | SPHK1LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL14158149 | 0.76 | LMNA (0.39) | LMNAPOLBSMN1; SMN2ALDH1A1GBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1529030-A2 | DERIVATIVES OF GLYCINERGIC R(+)-2-AMINO-3-HYDROXYPROPANOIC ACID | Prestwick Pharmaceuticals, Inc. (US) | 2005-05-11 | — | — | EP | disclosed |
| WO-2004016580-A2 | DERIVATIVES OF GLYCINERGIC R(+)-2-AMINO-3-HYDROXYPROPANOIC ACID | PRESTWICK PHARMACEUTICALS, INC. (US) | 2004-02-26 | — | — | WO | disclosed |