Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 8/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PGK1 | P00558 | 1/20 | 0.50 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236081 | 0.88 | RPS6KB2 (0.70) | RPS6KB2NPC1RAB9ASRPK1ADORA2A | |
| SCHEMBL6243113 | 0.88 | RPS6KB2 (0.70) | RPS6KB2NPC1RAB9APGK1SRPK1 | |
| SCHEMBL6234970 | 0.81 | RPS6KB2 (0.60) | RPS6KB2NPC1RAB9APGK1SRPK1 | |
| SCHEMBL7243836 | 0.77 | RPS6KB2 (0.56) | RPS6KB2NPC1RAB9APGK1SRPK1 | |
| SCHEMBL8212724 | 0.77 | RPS6KB2 (0.61) | RPS6KB2PGK1SRPK1ADORA2AADORA1 | |
| SCHEMBL6234080 | 0.77 | RPS6KB2 (0.64) | RPS6KB2NPC1RAB9ASRPK1MAPT | |
| SCHEMBL7692571 | 0.75 | RPS6KB2 (1.00) | RPS6KB2NPC1RAB9ASRPK1ADORA2A | |
| SCHEMBL6239309 | 0.74 | RPS6KB2 (0.70) | RPS6KB2NPC1RAB9ASRPK1ADORA2A | |
| SCHEMBL13595008 | 0.74 | PGK1 (0.53) | RPS6KB2NPC1RAB9APGK1SRPK1 | |
| SCHEMBL13594785 | 0.74 | RPS6KB2 (0.50) | RPS6KB2NPC1RAB9APGK1SRPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007099-A2 | PKB INHIBITORS AS ANTI-TUMOR AGENTS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-01-27 | — | — | WO | disclosed |