Gsk-182497A

Gsk-182497A

SCHEMBL6236347

CN(C)C(=O)O[C@H]1CN[C@H](C#Cc2cc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3s2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 1.00
ERBB2 P04626 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gsk-182497A SCHEMBL6235435 1.00 EGFR (1.00) EGFRERBB2
Gsk-182497A SCHEMBL6235426 1.00 EGFR (1.00) EGFRERBB2
Gsk-238063A SCHEMBL6241800 1.00 EGFR (1.00) EGFRERBB2
Gsk-182497A SCHEMBL6236489 1.00 EGFR (1.00) EGFRERBB2
SCHEMBL6241239 0.94 EGFR (1.00) EGFRERBB2
SCHEMBL6241231 0.94 EGFR (1.00) EGFRERBB2
SCHEMBL6240518 0.94 EGFR (0.89) EGFRERBB2
SCHEMBL6240523 0.94 EGFR (0.89) EGFRERBB2
SCHEMBL6241187 0.94 EGFR (1.00) EGFRERBB2
SCHEMBL6241180 0.94 EGFR (1.00) EGFRERBB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230190748-A1 COMPOSITIONS FOR TREATMENT OF AGED DISEASES GERO PTE LTD (SG) 2023-06-22 US claimed
WO-2005007083-A2 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2005-01-27 WO claimed
US-20230190748-A1 COMPOSITIONS FOR TREATMENT OF AGED DISEASES GERO PTE LTD (SG) 2023-06-22 US disclosed
WO-2005007083-A2 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 2005-01-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230190748-A1 COMPOSITIONS FOR TREATMENT OF AGED DISEASES AGER, CKMT1A; CKMT1B, GLA EGFR 1153/4885ERBB2 1599/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.