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Beminafil

Beminafil

SCHEMBL6236544

COc1ccc(CNc2nc([C@H]3CC[C@H](C(=O)O)CC3)nc3sc4ccccc4c23)cc1Cl.[Na]

nearest known ligand 0.46

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Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PDE5A O76074 15/20 0.46
▸ PDE11A Q9HCR9 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Beminafil SCHEMBL2421274 0.99 PDE5A (0.47) PDE5APDE11A
Beminafil SCHEMBL29385559 0.99 PDE5A (0.47) PDE5APDE11A
Beminafil SCHEMBL2421268 0.99 PDE5A (0.47) PDE5APDE11A
Beminafil SCHEMBL29419601 0.95 PDE5A (0.44) PDE5APDE11A
Beminafil SCHEMBL29382322 0.95 PDE5A (0.44) PDE5APDE11A
Beminafil SCHEMBL7124593 0.95 PDE5A (0.44) PDE5APDE11A
SCHEMBL6760546 0.93 PDE5A (0.41) PDE5APDE11A
Beminafil SCHEMBL6236540 0.92 PDE5A (0.41) PDE5APDE11A
SCHEMBL6763383 0.92 PDE5A (0.42) PDE5APDE11A
SCHEMBL6764887 0.91 MEN1 (0.40) PDE5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1543832-A2 Use of trans-4[4-(3-chloro-4-methoxy-benzylamino) benzothieno[2,3-d]pyrimidin-2-yl]-cyclohexanecarboxylic acid in the treatment of extrapyramidal movement disorders MERCK PATENT GmbH (DE) 2005-06-22 — — EP disclosed