Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.85 |
| ▸ | MAPT | P10636 | 3/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.85 |
| ▸ | HPGD | P15428 | 1/20 | 0.85 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.85 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.85 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.65 |
| ▸ | PARP1 | P09874 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6351333 | 0.99 | KDM4E (0.83) | KDM4EMAPTALDH1A1HPGDMTNR1A | |
| SCHEMBL3033917 | 0.92 | KDM4E (1.00) | KDM4EMAPTALDH1A1HPGDMTNR1A | |
| SCHEMBL34463671 | 0.92 | KDM4E (1.00) | KDM4EMAPTALDH1A1HPGDMTNR1A | |
| SCHEMBL34463669 | 0.92 | KDM4E (1.00) | KDM4EMAPTALDH1A1HPGDMTNR1A | |
| SCHEMBL9920131 | 0.84 | KDM4E (0.61) | KDM4EMAPTALDH1A1HPGDMTNR1A | |
| SCHEMBL4142893 | 0.82 | KDM4E (0.69) | KDM4EMAPTALDH1A1HPGDMTNR1A | |
| SCHEMBL6234998 | 0.82 | KDM4E (0.65) | KDM4EMAPTALDH1A1HPGDMTNR1A | |
| SCHEMBL15472018 | 0.82 | KDM4E (0.84) | KDM4EMAPTALDH1A1HPGDMTNR1A | |
| SCHEMBL4903858 | 0.81 | KDM4E (0.80) | KDM4EMAPTALDH1A1HPGDMTNR1A | |
| Hydrochloric Acid SCHEMBL4901475 | 0.80 | KDM4E (0.78) | KDM4EMAPTALDH1A1HPGDMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023787-B2 | MAPKAP kinase-2 as a specific target for blocking proliferation of P53-defective | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-05-05 | — | — | US | disclosed |
| US-20140037755-A1 | Mapkap Kinase-2 as a Specific Target for Blocking Proliferation of P53-Defective Cells | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2014-02-06 | — | — | US | disclosed |
| US-20050143371-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-30 | — | — | US | disclosed |
| WO-2005009370-A2 | BETA-CARBOLINE COMPOUNDS AND ANALOGUES THEREOF AND THEIR USE AS MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS | PHARMACIA CORPORATION (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140037755-A1 | Mapkap Kinase-2 as a Specific Target for Blocking Proliferation of P53-Defective Cells | MAPKAPK2, MAPKAP1, MAP3K2 | KDM4E 4005/4885MAPT 1844/4885ALDH1A1 3467/4885 |
| US-20050143371-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | MAP4K2, MAPKAPK2, MAP3K2 | KDM4E 2254/4885MAPT 2076/4885ALDH1A1 3919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.