Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234998 | 0.97 | KDM4E (0.65) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL8794276 | 0.91 | KDM4E (0.68) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL4109708 | 0.89 | HSD17B10 (0.59) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL2553660 | 0.82 | PARP1 (0.69) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL6236714 | 0.82 | KDM4E (0.85) | KDM4EALDH1A1LMNAHPGDMAPT | |
| SCHEMBL4156339 | 0.82 | KDM4E (0.61) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL13852787 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1LMNAPOLBHPGD | |
| Hydrochloric Acid SCHEMBL6351333 | 0.81 | KDM4E (0.83) | KDM4EALDH1A1LMNAHPGDMAPT | |
| SCHEMBL4031072 | 0.81 | KDM4E (1.00) | KDM4EALDH1A1LMNAPOLBHPGD | |
| SCHEMBL13852919 | 0.80 | CYP1A2 (0.67) | KDM4EALDH1A1LMNAPOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118666733-A | Application of tetrahydrocarbazole micromolecule compounds in preparation of antiviral drugs and preparation method thereof | 中国人民解放军空军军医大学 | 2024-09-20 | — | — | CN | disclosed |
| WO-2023088388-A1 | TETRAHYDROCARBAZOLE COMPOUND, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 杭州拿因生物科技有限责任公司 | 2023-05-25 | — | — | WO | disclosed |
| US-11458121-B2 | Therapeutic compounds and methods to treat infection | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2022-10-04 | — | — | US | disclosed |
| CN-107739371-B | Tetrahydrocarbazole micromolecule organic compound, application thereof in preparing antibacterial drugs and preparation method thereof | 华东师范大学 | 2020-08-25 | — | — | CN | disclosed |
| US-20200155507-A1 | THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2020-05-21 | — | — | US | disclosed |
| US-20200155507-A1 | THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2020-05-21 | — | — | US | disclosed |
| WO-2019005841-A1 | THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2019-01-03 | — | — | WO | disclosed |
| WO-2019005841-A1 | THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2019-01-03 | — | — | WO | disclosed |
| US-7622494-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-24 | — | — | US | disclosed |
| US-7622494-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-24 | — | — | US | disclosed |
| WO-2006121466-A2 | HCV INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-16 | — | — | WO | disclosed |
| US-20060161002-A1 | Tetrahydrocarbazole derivatives and their pharmaceutical use | SMITHKLINE BEECHAM CORPORATION | 2006-07-20 | — | — | US | disclosed |
| EP-1658068-A1 | NOVEL CYCLOALKYL'B! CONDENSED INDOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-24 | — | — | EP | disclosed |
| EP-1654228-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005023245-A1 | NOVEL CYCLOALKYL’B! CONDENSED INDOLES | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-17 | — | — | WO | disclosed |
| WO-2004110999-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORPORATION (US) | 2004-12-23 | — | — | WO | disclosed |
| EP-0028270-B1 | PYRAZINO-CARBAZOLES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CASSELLA Aktiengesellschaft (DE) | 1983-02-16 | — | — | EP | disclosed |
| US-4271073-A | ANTIDEPRESSANTS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1981-06-02 | — | — | US | disclosed |
| EP-0028270-A1 | Pyrazino-carbazoles, process for their preparation and pharmaceutical compositions containing them | CASSELLA Aktiengesellschaft (DE) | 1981-05-13 | — | — | EP | disclosed |
| US-4258043-A | ANTIDEPRESSANTS | CASSELLA AKTIENGESELLSCHAFT (DE) | 1981-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11458121-B2 | Therapeutic compounds and methods to treat infection | ABCB11, SLC10A1, SLC47A1 | KDM4E 4461/4885ALDH1A1 617/4885LMNA 4360/4885 |
| US-20060161002-A1 | Tetrahydrocarbazole derivatives and their pharmaceutical use | HMBS, UGT2B17, TPMT | KDM4E 1909/4885ALDH1A1 1218/4885LMNA 2715/4885 |
| US-20200155507-A1 | THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION | ABCB11, SLC10A1, SLC47A1 | KDM4E 4461/4885ALDH1A1 617/4885LMNA 4360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.