Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 6/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6232457 | 1.00 | ESRRA (0.61) | ESRRAHPGDFOXM1PTPN1CYP3A4 | |
| SCHEMBL6232460 | 1.00 | ESRRA (0.61) | ESRRAHPGDFOXM1PTPN1CYP3A4 | |
| SCHEMBL7458048 | 0.84 | ESRRA (0.62) | ESRRAFOXM1PTPN1CYP3A4PPARG | |
| SCHEMBL7458053 | 0.84 | ESRRA (0.62) | ESRRAFOXM1PTPN1CYP3A4PPARG | |
| SCHEMBL6232813 | 0.81 | PPARA (0.62) | PPARGPPARA | |
| SCHEMBL6235532 | 0.79 | ESRRA (0.60) | ESRRAHPGDFOXM1PTPN1CYP3A4 | |
| SCHEMBL6235536 | 0.79 | ESRRA (0.60) | ESRRAHPGDFOXM1PTPN1CYP3A4 | |
| SCHEMBL7459355 | 0.76 | PIM1 (0.71) | ESRRAHPGDPIM1PIM2PDE4B | |
| SCHEMBL7459357 | 0.76 | PIM1 (0.71) | ESRRAHPGDPIM1PIM2PDE4B | |
| SCHEMBL7457209 | 0.76 | PIM1 (0.71) | ESRRAHPGDCYP3A4PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1213287-B1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN SEIYAKU KK (JP) | 2005-05-25 | — | — | EP | disclosed |
| US-6730687-B1 | THERAPY OF METABOLIC DISEASES SUCH AS DIABETES AND HYPERLIPIDEMIA AS AGONISTS OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-05-04 | — | — | US | disclosed |
| EP-1213287-A1 | SUBSTITUTED BENZYLTHIAZOLIDINE-2,4-DIONE DERIVATIVES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-06-12 | — | — | EP | disclosed |