Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619264 | 1.00 | HPGD (0.68) | HPGDLMNAALDH1A1PKMMEN1 | |
| SCHEMBL29760295 | 1.00 | HPGD (0.68) | HPGDLMNAALDH1A1PKMMEN1 | |
| SCHEMBL21771179 | 0.88 | HPGD (0.62) | HPGDLMNAALDH1A1PKMMEN1 | |
| SCHEMBL2644150 | 0.84 | KDM4E (0.66) | HPGDLMNAALDH1A1PKMMEN1 | |
| SCHEMBL22036370 | 0.84 | HPGD (0.59) | HPGDLMNAALDH1A1PKMMEN1 | |
| SCHEMBL19828935 | 0.84 | HPGD (0.58) | HPGDLMNAALDH1A1PKMMEN1 | |
| SCHEMBL30296389 | 0.84 | KDM4E (0.66) | HPGDLMNAALDH1A1PKMMEN1 | |
| SCHEMBL28326301 | 0.84 | L3MBTL1 (0.58) | HPGDLMNAALDH1A1PKMMEN1 | |
| SCHEMBL18828359 | 0.80 | HPGD (0.56) | HPGDLMNAALDH1A1PKMMEN1 | |
| SCHEMBL9188836 | 0.80 | L3MBTL1 (0.61) | HPGDLMNAALDH1A1PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1528923-A1 | N-((3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL)ACETYL)GUANIDINE DERIVATIVES AS NHE1-INHIBITORS FOR THE TREATMENT OF INFARCTION AND ANGINA PECTORIS | Aventis Pharma Deutschland GmbH (DE) | 2005-05-11 | — | — | EP | disclosed |
| WO-2003101450-A1 | N- ((3-OXO2, 3-DIHYDRO-1H-ISOINDOL-1-YL) ACETYL) GUANIDINE DERIVATIVES AS NHE-1 INHIBITORS FOR THE TREATMENT OF INFARCTION AND ANGINA PECTORIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-12-11 | — | — | WO | disclosed |