⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3188988 | 0.85 | — | — | |
| SCHEMBL1860123 | 0.85 | — | — | |
| SCHEMBL8005919 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL20304575 | 0.83 | — | — | |
| SCHEMBL12193444 | 0.82 | ALDH1A1 (0.49) | — | |
| SCHEMBL12193442 | 0.82 | ALDH1A1 (0.49) | — | |
| SCHEMBL29538663 | 0.82 | ALDH1A1 (0.49) | — | |
| SCHEMBL6199139 | 0.81 | TSHR (0.41) | — | |
| SCHEMBL25125562 | 0.79 | — | — | |
| SCHEMBL16129841 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024041573-A1 | FUSED MULTI-HETEROCYCLIC COMPOUNDS AS KRAS G12D MODULATORS AND USES THEREOF | ZAI LAB (SHANGHAI) CO., LTD. (CN) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024032703-A1 | HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | BEIGENE, LTD. (KY) | 2024-02-15 | — | — | WO | disclosed |
| EP-1536841-A1 | MONITORING AND DIAGNOSIS OF GASTRIC EMPTYING AND GASTROPARESIS | The University of Chicago (US) | 2005-06-08 | — | — | EP | disclosed |
| CN-1187331-C | Esters of 3-hydroxy-piperidinemethanol derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2005-02-02 | — | — | CN | disclosed |
| CN-1187331-C | Esters of 3-hydroxy-piperidinemethanol derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2005-02-02 | — | — | CN | disclosed |
| US-20040126318-A1 | Methods, formulations and kits for monitoring and diagnosing gastric emptying and gastroparesis, and formulations for determining gastrointestinal motility | UNIVERSITY OF CHICAGO | 2004-07-01 | — | — | US | disclosed |
| WO-2004024192-A1 | MONITORING AND DIAGNOSIS OF GASTRIC EMPTYING AND GASTROPARESIS | UNIVERSITY OF CHICAGO (US) | 2004-03-25 | — | — | WO | disclosed |
| US-6096761-A | REACTING A N-SUBSTITUTED 4-METHANOL-3-HYDROXY OR ALKOXY-PIPERIDINE INTERMEDIATE WITH A CARBOXYLIC ACID DERIVATIVES; ADMINISTERING TO AN ANIMAL SUFFERING WITH A CONDITION RELATED TO HAMPERED OR IMPAIRED GASTRIC EMPTYING | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-08-01 | — | — | US | disclosed |
| EP-0666265-B1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2000-01-26 | — | — | EP | disclosed |
| CN-1205004-A | Novel esters of 3-hydroxy-piperidinemethanol derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1999-01-13 | — | — | CN | disclosed |
| CN-1205004-A | Novel esters of 3-hydroxy-piperidinemethanol derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1999-01-13 | — | — | CN | disclosed |
| US-5527786-A | ANTIDIABETIC AGENTS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0666265-A1 | PHOSPHONIC DIESTER DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-08-09 | — | — | EP | disclosed |