⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL320785 | 0.77 | — | — | |
| SCHEMBL12151306 | 0.71 | — | — | |
| SCHEMBL182910 | 0.69 | — | — | |
| SCHEMBL20252828 | 0.69 | NQO1 (0.33) | — | |
| SCHEMBL16075151 | 0.67 | — | — | |
| SCHEMBL24131434 | 0.66 | PGR (0.32) | — | |
| SCHEMBL4379207 | 0.66 | KDM4E (0.48) | — | |
| SCHEMBL26585312 | 0.66 | MAPT (0.43) | — | |
| SCHEMBL7038286 | 0.65 | — | — | |
| SCHEMBL7051061 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2568994-A2 | PROTEASE CATALYZED IN SITU END CAPPING OF OLIGOPEPTIDES IN AQUEOUS MEDIA | Polytechnic Institute of New York University (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143383-A9 | PROTEASE CATALYZED IN SITU END CAPPING OF OLIGOPEPTIDES IN AQUEOUS MEDIA | POLYTECHNIC INSTITUTE OF NEW YORK UNIVERSITY (US) | 2012-02-16 | — | — | WO | disclosed |
| US-20110287479-A1 | PROTEASE CATALYZED IN SITU END CAPPING OF OLIGOPEPTIDES IN AQUEOUS MEDIA | POLYTECHNIC INSTITUTE OF NEW YORK UNIVERSITY (US) | 2011-11-24 | — | — | US | disclosed |
| WO-2011143383-A2 | PROTEASE CATALYZED IN SITU END CAPPING OF OLIGOPEPTIDES IN AQUEOUS MEDIA | POLYTECHNIC INSTITUTE OF NEW YORK UNIVERSITY (US) | 2011-11-17 | — | — | WO | disclosed |
| CN-100369898-C | Nicotinamide derivates useful as p38 inhibitors | SMITHKLINE BEECHAM CORP (US) | 2008-02-20 | — | — | CN | disclosed |
| EP-1438310-B1 | BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS | TRANSTECH PHARMA INC (US) | 2006-12-20 | — | — | EP | disclosed |
| US-6933303-B2 | Heteroaryl-fused nitrogen heterocycles as therapeutic agents | TRANSTECH PHARMA, INC. (US) | 2005-08-23 | — | — | US | disclosed |
| CN-1633416-A | Nicotinamide derivatives as p38 inhibitors | SMITHKLINE BEECHAM CORP (US) | 2005-06-29 | — | — | CN | disclosed |
| US-20050096335-A1 | Heteroaryl - fused nitrogen heterocycles as therapeutic agents | TRANSTECH PHARMA, INC. | 2005-05-05 | — | — | US | disclosed |
| EP-1438310-A1 | BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS | TransTech Pharma Inc. (US) | 2004-07-21 | — | — | EP | disclosed |
| US-20040014778-A1 | Heteroaryl - fused nitrogen heterocycles as therapeutic agents | VTVX HOLDINGS I LLC | 2004-01-22 | — | — | US | disclosed |
| WO-2003033496-A1 | BETA-CARBOLIN DERIVATIVES AS PTP-INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2003-04-24 | — | — | WO | disclosed |