Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 17/20 | 0.66 |
| ▸ | HNF4A | P41235 | 4/20 | 0.66 |
| ▸ | RXRB | P28702 | 7/20 | 0.52 |
| ▸ | RXRG | P48443 | 6/20 | 0.52 |
| ▸ | RARA | P10276 | 3/20 | 0.52 |
| ▸ | RARB | P10826 | 3/20 | 0.52 |
| ▸ | RARG | P13631 | 3/20 | 0.52 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.50 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6242419 | 0.95 | RXRA (0.62) | RXRAHNF4ARXRBRXRGRARA | |
| SCHEMBL6239714 | 0.91 | RXRA (0.63) | RXRAHNF4ARXRBRXRGRARA | |
| SCHEMBL6242226 | 0.89 | RXRA (0.60) | RXRAHNF4ARXRBRXRGRARA | |
| SCHEMBL6236447 | 0.88 | RXRA (0.59) | RXRAHNF4ARXRBRXRGRARA | |
| SCHEMBL6240733 | 0.79 | RXRA (1.00) | RXRAHNF4ARXRBRXRGRARA | |
| SCHEMBL6889522 | 0.79 | RXRA (1.00) | RXRAHNF4ARXRBRXRGRARA | |
| SCHEMBL2685029 | 0.79 | RXRA (0.76) | RXRAHNF4ARXRBRXRGRARA | |
| SCHEMBL6905874 | 0.78 | RXRA (0.74) | RXRAHNF4ARXRBRXRGRARA | |
| SCHEMBL6244597 | 0.78 | RXRA (0.86) | RXRAHNF4ARXRBRXRGRARA | |
| SCHEMBL6242056 | 0.77 | RXRA (0.77) | RXRAHNF4ARXRBRXRGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005017185-A2 | HEPATOCYTE NUCLEAR FACTOR 4α MODULATOR COMPOUNDS | LIGAND PHARMCEUTICALS INCORPORATED (US) | 2005-02-24 | — | — | WO | disclosed |