Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Mephentermine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPRA | P18433 | 1/20 | 0.43 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mephentermine SCHEMBL121177 | 1.00 | LMNA (0.78) | LMNACYP2D6CYP3A4ALDH1A1CYP2C9 | |
| Mephentermine SCHEMBL3256311 | 1.00 | LMNA (0.78) | LMNACYP2D6CYP3A4ALDH1A1CYP2C9 | |
| Mephentermine SCHEMBL121178 | 0.88 | LMNA (1.00) | LMNACYP2D6CYP3A4ALDH1A1CYP2C9 | |
| Sulfuric Acid SCHEMBL15455773 | 0.81 | LMNA (0.48) | LMNACYP2D6CYP3A4ALDH1A1CYP2C9 | |
| Phentermine SCHEMBL28338903 | 0.77 | SLC6A2 (0.76) | LMNACYP2D6CYP3A4ALDH1A1KDM4E | |
| SCHEMBL6335183 | 0.76 | LMNA (0.57) | LMNACYP2D6CYP3A4ALDH1A1CYP2C9 | |
| Sulfuric Acid SCHEMBL5465234 | 0.76 | SLC6A2 (0.55) | LMNACYP2D6CYP3A4ALDH1A1CYP2C9 | |
| Phentermine SCHEMBL28815884 | 0.76 | SLC6A2 (0.73) | LMNACYP2D6CYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL6726914 | 0.75 | SLC6A2 (0.48) | LMNACYP2D6CYP3A4ALDH1A1CYP2C9 | |
| SCHEMBL8613504 | 0.74 | LMNA (0.65) | LMNACYP2D6CYP3A4ALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| EP-1534239-A2 | PREPARATION OF SUBMICRON SIZED PARTICLES WITH POLYMORPH CONTROL AND NEW POLYMORPH OF ITRACONAZOLE | BAXTER INTERNATIONAL INC. (US) | 2005-06-01 | — | — | EP | disclosed |
| EP-1438942-A1 | An otorhinological drug delivery device | Schering Oy (FI) | 2004-07-21 | — | — | EP | disclosed |
| WO-2004054500-A2 | PREPARATION OF SUBMICRON SIZED PARTICLES WITH POLYMORPH CONTROL AND NEW POLYMORPH OF ITRACONAZOLE | BAXTER INTERNATIONAL INC. (US) | 2004-07-01 | — | — | WO | disclosed |
| US-20030096013-A1 | Preparation of submicron sized particles with polymorph control | BAXTER INTERNATIONAL INC. | 2003-05-22 | — | — | US | disclosed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | disclosed |