Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GRK2 | P25098 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624460 | 0.82 | MAPT (0.44) | KMT2AMEN1MAPTALOX5KDM4E | |
| SCHEMBL10288198 | 0.76 | MEN1 (0.46) | KMT2AMEN1MAPTALOX5KDM4E | |
| SCHEMBL623525 | 0.76 | KMT2A (0.49) | KMT2AMEN1MAPTALOX5KDM4E | |
| SCHEMBL5747523 | 0.76 | RAB9A (0.52) | KMT2AMEN1MAPTALOX5KDM4E | |
| SCHEMBL624223 | 0.75 | SMN1; SMN2 (0.58) | KMT2AMEN1MAPTKDM4ELMNA | |
| SCHEMBL622975 | 0.74 | RAB9A (0.60) | KMT2AMEN1MAPTKDM4ERAB9A | |
| SCHEMBL623027 | 0.74 | MAPT (0.47) | KMT2AMEN1MAPTALOX5KDM4E | |
| SCHEMBL623495 | 0.73 | CDC7 (0.51) | KMT2AMEN1MAPTALOX5KDM4E | |
| Hydrochloric Acid SCHEMBL623549 | 0.73 | MAPT (0.46) | KMT2AMEN1MAPTALOX5KDM4E | |
| SCHEMBL27905821 | 0.72 | MAPT (0.54) | KMT2AMEN1MAPTKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603214-A1 | HETEROARYLS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012021696-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-02-16 | — | — | WO | disclosed |