Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.59 |
| ▸ | EGFR | P00533 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | F9 | P00740 | 1/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6240062 | 0.86 | EGFR (0.53) | ABCG2EGFRMAPTSYKDYRK1A | |
| SCHEMBL9726894 | 0.83 | ABCG2 (0.54) | ABCG2EGFRSYKDYRK1ADYRK1B | |
| SCHEMBL3061494 | 0.81 | EGFR (0.62) | EGFRMAPTTP53ERBB2 | |
| SCHEMBL5973657 | 0.81 | SYK (0.48) | ABCG2EGFRMAPTCDC7SYK | |
| SCHEMBL16179041 | 0.79 | EGFR (0.48) | ABCG2EGFRF9SYK | |
| SCHEMBL6237775 | 0.79 | EGFR (0.61) | ABCG2EGFRERBB2 | |
| SCHEMBL1898192 | 0.78 | EGFR (0.53) | ABCG2EGFRMAPTDYRK1ADYRK1B | |
| SCHEMBL4264905 | 0.76 | EGFR (0.51) | ABCG2EGFRMAPTTP53F9 | |
| SCHEMBL17802566 | 0.75 | ROCK1 (0.51) | EGFRMAPTERBB2 | |
| SCHEMBL27931003 | 0.75 | TTBK1 (0.66) | ABCG2EGFRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009384-A2 | EGFR TYROSINE KINASE INHIBITORS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |