Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.61 |
| ▸ | FBP1 | P09467 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3061494 | 0.85 | EGFR (0.62) | EGFRFBP1ERBB2 | |
| SCHEMBL1898192 | 0.81 | EGFR (0.53) | EGFRERBB2AURKBABCG2 | |
| SCHEMBL4272921 | 0.79 | EGFR (0.53) | EGFRFBP1AURKAAURKBINCENP | |
| SCHEMBL6240062 | 0.79 | EGFR (0.53) | EGFRFBP1ERBB2AURKAAURKB | |
| SCHEMBL6237576 | 0.79 | ABCG2 (0.59) | EGFRERBB2ABCG2 | |
| SCHEMBL8318036 | 0.78 | EGFR (0.60) | EGFRFBP1ABCG2 | |
| SCHEMBL17802566 | 0.78 | ROCK1 (0.51) | EGFRERBB2AURKA | |
| SCHEMBL6215346 | 0.76 | GRM4 (0.45) | EGFRERBB2 | |
| SCHEMBL1896427 | 0.74 | TTBK1 (0.55) | EGFR | |
| SCHEMBL29608178 | 0.74 | EGFR (1.00) | EGFRFBP1ERBB2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009384-A2 | EGFR TYROSINE KINASE INHIBITORS | IMCLONE SYSTEMS INCORPORATED (US) | 2005-02-03 | — | — | WO | disclosed |