Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.52 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21596090 | 0.86 | KDM4E (0.56) | TDP1MAPTTSHRHPGDRAB9A | |
| SCHEMBL29364868 | 0.80 | RAB9A (0.78) | TDP1MAPTTSHRHPGDRAB9A | |
| SCHEMBL116448 | 0.80 | RAB9A (0.78) | TDP1MAPTTSHRHPGDRAB9A | |
| SCHEMBL1496045 | 0.80 | TDP1 (0.70) | TDP1MAPTTSHRHPGDRAB9A | |
| SCHEMBL6273809 | 0.80 | MAPT (0.52) | TDP1MAPTTSHRHPGDRAB9A | |
| Ammonia Solution, Strong SCHEMBL8439387 | 0.79 | TDP1 (0.68) | TDP1MAPTTSHRHPGDRAB9A | |
| SCHEMBL11626260 | 0.79 | TDP1 (0.63) | TDP1MAPTTSHRHPGDRAB9A | |
| SCHEMBL10381793 | 0.79 | RAB9A (0.72) | TDP1MAPTTSHRHPGDRAB9A | |
| Hydrochloric Acid SCHEMBL11002766 | 0.79 | RAB9A (0.76) | TDP1MAPTTSHRHPGDRAB9A | |
| SCHEMBL11413525 | 0.78 | S1PR4 (0.66) | TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539687-A1 | SUBSTITUTED GLYCINE DERIVATIVES FOR USE AS MEDICAMENTS | Pfizer Limited (GB) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004016583-A1 | SUBSTITUTED GLYCINE DERIVATIVES FOR USE AS MEDICAMENTS | PFIZER LIMITED (GB) | 2004-02-26 | — | — | WO | disclosed |