⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003406 | 0.69 | ALDH1A1 (0.40) | — | |
| Formaldehyde SCHEMBL27942429 | 0.65 | CA4 (0.38) | — | |
| SCHEMBL924562 | 0.64 | — | — | |
| SCHEMBL3008677 | 0.64 | — | — | |
| SCHEMBL691694 | 0.64 | — | — | |
| SCHEMBL7262793 | 0.64 | — | — | |
| SCHEMBL12892552 | 0.64 | — | — | |
| Ammonia Solution, Strong SCHEMBL23611461 | 0.62 | — | — | |
| Bromide SCHEMBL9014902 | 0.62 | — | — | |
| Hydrochloric Acid SCHEMBL1304764 | 0.62 | CA4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143371-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-30 | — | — | US | claimed |
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-23 | — | — | US | claimed |
| US-20050143371-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-30 | — | — | US | disclosed |
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-23 | — | — | US | disclosed |
| WO-2005009370-A2 | BETA-CARBOLINE COMPOUNDS AND ANALOGUES THEREOF AND THEIR USE AS MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS | PHARMACIA CORPORATION (US) | 2005-02-03 | — | — | WO | disclosed |
| EP-0344707-A2 | 2-Oxo-1-[[(substituted sulfonyl)-amino]carbonyl]-azetidine derivatives | E.R. SQUIBB & SONS, INC. (US) | 1989-12-06 | — | — | EP | disclosed |
| EP-0321928-A2 | 2-Oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines | E.R. SQUIBB & SONS, INC. (US) | 1989-06-28 | — | — | EP | disclosed |