Sugi Predict

Sugi Predict / Compounds / SCHEMBL6239256

SCHEMBL6239256

SCHEMBL6239256

CN(C)CCOc1ccc2c(c1)c(O)c(C1=NS(=O)(=O)c3ccccc3N1)c(=O)n2CCC1CC1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2C9 P11712 3/20 0.70
▸ NR1I2 O75469 1/20 0.70
▸ MAPK1 P28482 1/20 0.50
▸ HSD17B10 Q99714 1/20 0.50
▸ HIF1A Q16665 1/20 0.34
▸ HPGD P15428 1/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ USP2 O75604 1/20 0.33
▸ PIK3CA P42336 1/20 0.33
▸ PRKDC P78527 1/20 0.33
▸ FGFR1 P11362 1/20 0.32
▸ SRC P12931 1/20 0.32
▸ TOP2A P11388 1/20 0.32
▸ ESR1 P03372 1/20 0.32
▸ BACE1 P56817 1/20 0.32
▸ PRKCB P05771 1/20 0.32
▸ PRKCA P17252 1/20 0.32
▸ PRKCH P24723 1/20 0.32
▸ PRKCE Q02156 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6737865 0.91 CYP2C9 (0.74) CYP2C9NR1I2MAPK1HSD17B10HIF1A
SCHEMBL6738430 0.83 CYP2C9 (0.79) CYP2C9NR1I2MAPK1HSD17B10HIF1A
SCHEMBL6738190 0.83 CYP2C9 (0.81) CYP2C9NR1I2MAPK1HSD17B10HIF1A
SCHEMBL5089690 0.83 CYP2C9 (1.00) CYP2C9NR1I2MAPK1HSD17B10HIF1A
SCHEMBL6209924 0.82 CYP2C9 (0.80) CYP2C9NR1I2MAPK1HSD17B10HIF1A
SCHEMBL6267035 0.80 CYP2C9 (0.90) CYP2C9NR1I2MAPK1HSD17B10HIF1A
SCHEMBL6231106 0.80 CYP2C9 (0.77) CYP2C9NR1I2MAPK1HSD17B10MEN1
SCHEMBL6738292 0.79 CYP2C9 (0.65) CYP2C9NR1I2MAPK1HSD17B10HIF1A
SCHEMBL6739059 0.79 MAPK1 (0.57) CYP2C9NR1I2MAPK1HSD17B10HPGD
SCHEMBL6240041 0.79 MAPK1 (0.59) CYP2C9NR1I2MAPK1HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401443-A4 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORP (US) 2005-10-26 — — EP claimed
CN-1535151-A Novel anti-infectives ʷ��˿�������ȳ�ķ���޹�˾ 2004-10-06 — — CN claimed
US-20040147739-A1 Novel anti-infectives SMITHKLINE BEECHAM CORPORATION 2004-07-29 — — US claimed
EP-1401443-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2004-03-31 — — EP claimed
WO-2002098424-A1 NOVEL ANTI-INFECTIVES SMITHKLINE BEECHAM CORPORATION (US) 2002-12-12 — — WO claimed
CN-1535151-A Novel anti-infectives ʷ��˿�������ȳ�ķ���޹�˾ 2004-10-06 — — CN disclosed
US-20040147739-A1 Novel anti-infectives SMITHKLINE BEECHAM CORPORATION 2004-07-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040147739-A1 Novel anti-infectives RPL5, RPL7, RPL35 CYP2C9 1218/4885NR1I2 1798/4885MAPK1 3699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.