Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.58 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234161 | 0.90 | MAPKAPK2 (0.59) | MAPKAPK2MAPKAPK5PTGS1PTGS2MTNR1A | |
| Trifluoroacetic Acid SCHEMBL6350855 | 0.85 | MAPKAPK2 (0.53) | MAPKAPK2MAPKAPK5PTGS1PTGS2MTNR1A | |
| SCHEMBL16602554 | 0.83 | MAPKAPK2 (0.55) | MAPKAPK2MAPKAPK5 | |
| SCHEMBL7852873 | 0.80 | MAPKAPK2 (0.42) | MAPKAPK2MAPKAPK5PTGS1PTGS2MTNR1A | |
| SCHEMBL17945910 | 0.76 | MAPKAPK2 (0.52) | MAPKAPK2MAPKAPK5 | |
| SCHEMBL6240818 | 0.76 | MAPKAPK2 (0.56) | MAPKAPK2MAPKAPK5PTGS1PTGS2 | |
| SCHEMBL6235224 | 0.74 | MAPKAPK2 (1.00) | MAPKAPK2MAPKAPK5MAPT | |
| SCHEMBL6352708 | 0.74 | MAPKAPK2 (1.00) | MAPKAPK2MAPKAPK5MAPT | |
| SCHEMBL12660570 | 0.74 | MAPKAPK2 (1.00) | MAPKAPK2MAPKAPK5MAPT | |
| SCHEMBL608164 | 0.74 | MAPKAPK2 (1.00) | MAPKAPK2MAPKAPK5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-23 | — | — | US | disclosed |
| WO-2005009370-A2 | BETA-CARBOLINE COMPOUNDS AND ANALOGUES THEREOF AND THEIR USE AS MITOGEN-ACTIVATED PROTEIN KINASE-ACTIVATED PROTEIN KINASE-2 INHIBITORS | PHARMACIA CORPORATION (US) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | MAPKAPK2, MAP4K2, MAP3K2 | MAPKAPK2 1/4885MAPKAPK5 34/4885PTGS1 1384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.