Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.53 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6234161 | 0.93 | MAPKAPK2 (0.59) | MAPKAPK2MAPKAPK5MTNR1APTGS1PTGS2 | |
| Trifluoroacetic Acid SCHEMBL6356116 | 0.88 | MAPKAPK2 (0.50) | MAPKAPK2MAPKAPK5KDM1APTGS1PTGS2 | |
| SCHEMBL6239283 | 0.85 | MAPKAPK2 (0.58) | MAPKAPK2MAPKAPK5MTNR1APTGS1PTGS2 | |
| SCHEMBL6240818 | 0.80 | MAPKAPK2 (0.56) | MAPKAPK2MAPKAPK5PTGS1PTGS2 | |
| SCHEMBL7852873 | 0.73 | MAPKAPK2 (0.42) | MAPKAPK2MAPKAPK5MTNR1APTGS1PTGS2 | |
| SCHEMBL16602554 | 0.72 | MAPKAPK2 (0.55) | MAPKAPK2MAPKAPK5 | |
| SCHEMBL1491372 | 0.69 | MAPKAPK2 (1.00) | MAPKAPK2MAPKAPK5 | |
| Hydrochloric Acid SCHEMBL6352215 | 0.68 | MAPKAPK2 (0.98) | MAPKAPK2MAPKAPK5 | |
| Hydrochloric Acid SCHEMBL7684052 | 0.67 | KMT2A (0.44) | MAPKAPK2MAPKAPK5MTNR1A | |
| SCHEMBL11284818 | 0.67 | KDM4E (0.47) | MAPKAPK2MAPKAPK5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | PHARMACIA CORPORATION (US) | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137220-A1 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors | MAPKAPK2, MAP4K2, MAP3K2 | MAPKAPK2 1/4885MAPKAPK5 34/4885CFTR 4489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.