SCHEMBL6239498

SCHEMBL6239498

COc1cccc(CNC(=O)c2ccccc2-c2ccccc2C(=O)N(CCC(=O)O)Cc2ccc(F)cc2)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.62
ALDH1A1 P00352 3/20 0.51
HPGD P15428 2/20 0.51
KDM4E B2RXH2 1/20 0.51
USP2 O75604 1/20 0.51
APEX1 P27695 1/20 0.50
HDAC1 Q13547 2/20 0.47
HDAC6 Q9UBN7 2/20 0.47
LPAR1 Q92633 2/20 0.47
POLB P06746 2/20 0.47
LMNA P02545 1/20 0.47
HTT P42858 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
KCNK3 O14649 1/20 0.45
KCNK5 O95279 1/20 0.45
KCNA5 P22460 1/20 0.45
KCNK17 Q96T54 1/20 0.45
KCNK9 Q9NPC2 1/20 0.45
MMP13 P45452 2/20 0.45
LPAR5 Q9H1C0 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5397034 0.95 RAB9A (0.69) RAB9AALDH1A1HPGDKDM4EUSP2
SCHEMBL5392918 0.94 RAB9A (0.65) RAB9AALDH1A1HPGDKDM4EUSP2
SCHEMBL5406209 0.91 RAB9A (0.54) RAB9AALDH1A1HPGDKDM4EUSP2
SCHEMBL5403231 0.91 HDAC1 (0.55) RAB9AHPGDHDAC1HDAC6LPAR1
SCHEMBL5402486 0.91 HDAC1 (0.55) RAB9AHPGDHDAC1HDAC6LPAR1
SCHEMBL5409640 0.90 RAB9A (0.58) RAB9AALDH1A1HPGDKDM4EUSP2
SCHEMBL5418619 0.89 LPAR1 (0.47) RAB9AHDAC1HDAC6LPAR1LMNA
SCHEMBL5408917 0.88 KDM4E (0.48) RAB9AALDH1A1HPGDKDM4EHDAC1
SCHEMBL5399681 0.88 KMT2A (0.54) RAB9AALDH1A1HPGDKDM4EAPEX1
SCHEMBL5398638 0.88 KMT2A (0.54) RAB9AALDH1A1HPGDKDM4EAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1533294-A1 BETA-ALANINE DERIVATIVE AND USE THEREOF ONO PHARMACEUTICAL CO., LTD. (JP) 2005-05-25 EP disclosed