Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.53 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.50 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.50 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.50 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.50 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.49 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.49 |
| ▸ | OTC | P00480 | 1/20 | 0.48 |
| ▸ | DDAH1 | O94760 | 3/20 | 0.47 |
| ▸ | NOS1 | P29475 | 4/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 3/20 | 0.46 |
| ▸ | RRM1 | P23921 | 1/20 | 0.45 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL6242106 | 1.00 | DPP7 (0.53) | DPP7NOD1GNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL14742697 | 0.98 | DPP7 (0.54) | DPP7NOD1GNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL28855904 | 0.95 | DPP7 (0.54) | DPP7NOD1GNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL6238383 | 0.95 | DPP7 (0.54) | DPP7NOD1GNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL6242153 | 0.95 | DPP7 (0.54) | DPP7NOD1GNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL15902175 | 0.94 | OTC (0.50) | DPP7NOD1GNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL6148909 | 0.94 | OTC (0.50) | DPP7NOD1GNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL6239448 | 0.93 | NOD1 (0.49) | DPP7NOD1GNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL6243955 | 0.93 | NOD1 (0.49) | DPP7NOD1GNAI3GNAO1GNAI1 | |
| Arginine SCHEMBL6244144 | 0.92 | OTC (0.49) | DPP7NOD1GNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549669-A1 | TUMOR TARGETING AGENTS AND USES THEREOF | Karyon OY (FI) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031221-A9 | TUMOR TARGETING AGENTS AND USES THEREOF | KARYON OY (FI) | 2004-07-08 | — | — | WO | disclosed |
| WO-2004031221-A1 | TUMOR TARGETING AGENTS AND USES THEREOF | KARYON OY (FI) | 2004-04-15 | — | — | WO | disclosed |