Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6236195 | 0.97 | MAPK1 (0.68) | MAPK1HSD17B10CYP2C9NR1I2CHEK1 | |
| SCHEMBL6232243 | 0.90 | MAPK1 (0.66) | MAPK1HSD17B10CYP2C9NR1I2KDM4E | |
| SCHEMBL6236058 | 0.90 | MAPK1 (0.68) | MAPK1HSD17B10CYP2C9NR1I2CHEK1 | |
| SCHEMBL6732912 | 0.89 | MAPK1 (0.57) | MAPK1HSD17B10CYP2C9NR1I2CHEK1 | |
| SCHEMBL6232111 | 0.89 | MAPK1 (0.67) | MAPK1HSD17B10CYP2C9NR1I2KDM4E | |
| SCHEMBL6235524 | 0.89 | MAPK1 (0.67) | MAPK1HSD17B10CYP2C9NR1I2KDM4E | |
| SCHEMBL6236122 | 0.89 | MAPK1 (0.67) | MAPK1HSD17B10CYP2C9NR1I2KDM4E | |
| SCHEMBL6235167 | 0.88 | MAPK1 (0.66) | MAPK1HSD17B10CYP2C9NR1I2CHEK1 | |
| SCHEMBL6236792 | 0.88 | MAPK1 (0.66) | MAPK1HSD17B10CYP2C9NR1I2KDM4E | |
| SCHEMBL6741396 | 0.88 | MAPK1 (0.66) | MAPK1HSD17B10CYP2C9NR1I2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401443-A4 | NOVEL ANTI-INFECTIVES | SMITHKLINE BEECHAM CORP (US) | 2005-10-26 | — | — | EP | disclosed |
| EP-1401443-A1 | NOVEL ANTI-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-31 | — | — | EP | disclosed |
| WO-2002098424-A1 | NOVEL ANTI-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-12-12 | — | — | WO | disclosed |