Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5241746 | 0.91 | HTR6 (0.67) | HTR6ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL5242794 | 0.90 | HTR6 (0.66) | HTR6ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5240551 | 0.87 | HTR6 (0.72) | HTR6ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5243539 | 0.87 | HTR6 (0.67) | HTR6ALDH1A1L3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL3321950 | 0.86 | HTR6 (0.81) | HTR6CYP1A2CYP2D6CYP2C19HSD17B10 | |
| Hydrochloric Acid SCHEMBL5241623 | 0.86 | HTR6 (0.66) | HTR6ALDH1A1L3MBTL1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL5244077 | 0.86 | HTR6 (0.71) | HTR6ALDH1A1CYP1A2CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL5242993 | 0.85 | HTR6 (0.80) | HTR6CYP1A2CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL5241269 | 0.84 | HTR6 (0.66) | HTR6ALDH1A1L3MBTL1CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL5241407 | 0.83 | HTR6 (0.65) | HTR6ALDH1A1L3MBTL1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569638-A1 | AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004050085-A1 | AMINOALKOXYINDOLES AS 5-HT6-RECEPTOR LIGANDS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-17 | — | — | WO | disclosed |