Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.67 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.67 |
| ▸ | HCK | P08631 | 9/20 | 0.67 |
| ▸ | TNF | P01375 | 5/20 | 0.67 |
| ▸ | CIT | O14578 | 1/20 | 0.66 |
| ▸ | MUSK | O15146 | 1/20 | 0.66 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.66 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.66 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.66 |
| ▸ | STK10 | O94804 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | RAF1 | P04049 | 1/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.66 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.66 |
| ▸ | PRKCB | P05771 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365566 | 0.85 | MAPK14 (0.78) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL29593878 | 0.85 | MAPK14 (0.70) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL295776 | 0.85 | MAPK14 (0.70) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL29594339 | 0.85 | MAPK14 (0.79) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL294689 | 0.85 | MAPK14 (0.79) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL6298579 | 0.84 | MAPK14 (0.79) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL29593481 | 0.84 | MAPK14 (0.71) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL294715 | 0.84 | MAPK14 (0.71) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL29594248 | 0.83 | MAPK14 (0.84) | MAPK14MAPK12HCKTNFCIT | |
| SCHEMBL295934 | 0.83 | MAPK14 (0.84) | MAPK14MAPK12HCKTNFCIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3691620-A1 | P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD | Fulcrum Therapeutics, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019071147-A1 | P38 KINASE INHIBITORS REDUCE DUX4 AND DOWNSTREAM GENE EXPRESSION FOR THE TREATMENT OF FSHD | Fulcrum Therapeutics, Inc. (US) | 2019-04-11 | — | — | WO | disclosed |
| EP-1545514-A1 | ANTICOAGULANT AND FIBRINOLYTIC THERAPY USING P38 MAP KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-29 | — | — | EP | disclosed |
| EP-1408950-A2 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2004016267-A1 | ANTICOAGULANT AND FIBRINOLYTIC THERAPY USING P38 MAP KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-02-26 | — | — | WO | disclosed |
| WO-2003005999-A2 | METHODS OF TREATING CYTOKINE MEDIATED DISEASES | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-01-23 | — | — | WO | disclosed |