Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 15/20 | 0.65 |
| ▸ | IKBKE | Q14164 | 5/20 | 0.65 |
| ▸ | JAK1 | P23458 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4839205 | 0.93 | TBK1 (0.75) | TBK1IKBKEJAK1JAK2ACHE | |
| SCHEMBL4834843 | 0.92 | TBK1 (0.77) | TBK1IKBKEJAK1JAK2JAK3 | |
| SCHEMBL4833993 | 0.82 | TBK1 (0.79) | TBK1IKBKEJAK1JAK2JAK3 | |
| SCHEMBL4833971 | 0.80 | TBK1 (0.78) | TBK1IKBKEJAK1JAK2ACHE | |
| SCHEMBL4838932 | 0.80 | TBK1 (0.69) | TBK1IKBKEJAK1JAK2JAK3 | |
| SCHEMBL4846026 | 0.80 | TBK1 (1.00) | TBK1IKBKEJAK1JAK2JAK3 | |
| SCHEMBL4842291 | 0.77 | TBK1 (0.73) | TBK1IKBKEJAK1JAK2JAK3 | |
| SCHEMBL4842171 | 0.77 | TBK1 (0.65) | TBK1IKBKEJAK1ACHE | |
| SCHEMBL6249645 | 0.77 | TBK1 (0.77) | TBK1IKBKEJAK1ACHEAURKB | |
| SCHEMBL4840452 | 0.77 | TBK1 (0.72) | TBK1IKBKEJAK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539759-A1 | USE OF AND SOME NOVEL IMIDAZOPYRIDINES | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004016611-A1 | USE OF AND SOME NOVEL IMIDAZOPYRIDINES | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | WO | disclosed |