Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12047054 | 0.79 | SMN1; SMN2 (0.53) | KDM4EPOLBSMN1; SMN2AKR1C3AKR1C2 | |
| SCHEMBL1844946 | 0.77 | PPARD (0.52) | SLC6A9PPARDSMN1; SMN2SRD5A1CYP19A1 | |
| SCHEMBL8530718 | 0.76 | MTNR1A (0.45) | SLC6A9PPARDSRD5A1CYP19A1MTNR1A | |
| SCHEMBL6248750 | 0.75 | PPARD (0.38) | SLC6A9PPARDKDM4ESRD5A1MTNR1A | |
| SCHEMBL27989609 | 0.75 | SRD5A1 (0.50) | SLC6A9PPARDSMN1; SMN2SRD5A1CYP19A1 | |
| SCHEMBL19002290 | 0.74 | MTNR1A (0.51) | SLC6A9PPARDSRD5A1CYP19A1MTNR1A | |
| SCHEMBL820924 | 0.73 | PPARG (0.53) | SLC6A9PPARDSRD5A1MTNR1AMTNR1B | |
| SCHEMBL20214100 | 0.73 | PPARG (0.53) | SLC6A9PPARDSRD5A1MTNR1AMTNR1B | |
| SCHEMBL820921 | 0.73 | PPARG (0.53) | SLC6A9PPARDSRD5A1MTNR1AMTNR1B | |
| SCHEMBL6207342 | 0.73 | PPARG (0.53) | SLC6A9PPARDSRD5A1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256308-A1 | Spiro compounds, medicinal compositions containing the same and intermediates of the compounds | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 2005-11-17 | — | — | US | disclosed |
| EP-1559707-A1 | SPIRO COMPOUNDS, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THE COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 2005-08-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256308-A1 | Spiro compounds, medicinal compositions containing the same and intermediates of the compounds | ESRRA, ESR1, BRCA1 | SLC6A9 1546/4885PPARD 893/4885KDM4C 3370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.