Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.63 |
| ▸ | SGK1 | O00141 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.43 |
| ▸ | AKT2 | P31751 | 2/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4814869 | 0.83 | CHEK1 (0.89) | CHEK1SGK1AKT1AKT2AKT3 | |
| SCHEMBL6783209 | 0.78 | CHEK1 (1.00) | CHEK1 | |
| SCHEMBL6786553 | 0.73 | CHEK1 (1.00) | CHEK1SGK1AKT1AKT2AKT3 | |
| SCHEMBL4807605 | 0.73 | CHEK1 (0.60) | CHEK1KDRKCNH2 | |
| SCHEMBL6789849 | 0.73 | CHEK1 (0.79) | CHEK1SGK1AKT1AKT2AKT3 | |
| SCHEMBL6787533 | 0.73 | CHEK1 (0.79) | CHEK1SGK1AKT1AKT2AKT3 | |
| SCHEMBL6789540 | 0.71 | CHEK1 (0.81) | CHEK1SGK1AKT1AKT2AKT3 | |
| SCHEMBL6243766 | 0.69 | CHEK1 (0.57) | CHEK1KDR | |
| SCHEMBL4810299 | 0.68 | CHEK1 (1.00) | CHEK1KDRKCNH2 | |
| SCHEMBL4811512 | 0.67 | CHEK1 (1.00) | CHEK1KDRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603885-A1 | FUSED TRI AND TETRA-CYCLIC PYRAZOLE KINASE INHIBITORS | Abbott Laboratories (US) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004080973-A1 | FUSED TRI AND TETRA-CYCLIC PYRAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-09-23 | — | — | WO | disclosed |