Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 6/20 | 0.41 |
| ▸ | SRC | P12931 | 5/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | HCK | P08631 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.41 |
| ▸ | PRKDC | P78527 | 3/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.41 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812688 | 0.89 | EGFR (0.44) | EGFRERBB2IGF1RFGFR1BTK | |
| SCHEMBL4826519 | 0.87 | FGFR1 (0.59) | EGFRERBB2IGF1RFGFR1BTK | |
| SCHEMBL5819727 | 0.85 | NTRK1 (0.44) | EGFRBTKSRCKDRMAP4K3 | |
| SCHEMBL6247706 | 0.81 | SRC (0.44) | EGFRBTKSRCKDRPIK3CD | |
| SCHEMBL5822805 | 0.79 | SRC (0.40) | EGFRFGFR1SRCKDRPIK3CD | |
| SCHEMBL6248834 | 0.78 | SRC (0.43) | EGFRERBB2IGF1RFGFR1BTK | |
| SCHEMBL4824869 | 0.78 | EGFR (0.57) | EGFRERBB2IGF1RFGFR1BTK | |
| SCHEMBL5817387 | 0.78 | LCK (0.46) | EGFRBTKSRCKDRPIK3CD | |
| SCHEMBL7112685 | 0.77 | KDM4E (0.41) | EGFRERBB2IGF1RBTKSRC | |
| SCHEMBL6272921 | 0.77 | EGFR (0.40) | EGFRFGFR1BTKSRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379528-A4 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH (DE) | 2005-12-07 | — | — | EP | disclosed |
| WO-2004100868-A2 | METHOD OF TREATING TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 2004-11-25 | — | — | WO | disclosed |
| EP-1379528-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GmbH (DE) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002076986-A1 | PYRAZOLOPYRIMIDINES AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO. KG (DE) | 2002-10-03 | — | — | WO | disclosed |