SCHEMBL6246396

SCHEMBL6246396

CCCc1c(OCCCCNc2ccc(-c3nn[nH]n3)cc2)ccc(CC=O)c1O

nearest known ligand 0.73

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 14/20 0.73
MEN1 O00255 2/20 0.50
TSHR P16473 2/20 0.50
KMT2A Q03164 2/20 0.50
CYP1A2 P05177 1/20 0.50
MAPT P10636 1/20 0.50
HSD17B10 Q99714 1/20 0.50
CYSLTR2 Q9NS75 5/20 0.49
CYSLTR1 Q9Y271 5/20 0.49
LMNA P02545 1/20 0.45
GLA P06280 1/20 0.45
CYP3A4 P08684 1/20 0.45
ALOX5 P09917 1/20 0.45
ALOX15 P16050 1/20 0.45
PTGS1 P23219 1/20 0.45
PTGS2 P35354 1/20 0.45
TDP1 Q9NUW8 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6245223 0.99 GRM2 (0.72) GRM2MEN1TSHRKMT2ACYP1A2
SCHEMBL6245203 0.89 GRM2 (0.71) GRM2MEN1TSHRKMT2ACYP1A2
SCHEMBL6243454 0.85 GRM2 (0.56) GRM2MEN1TSHRKMT2ACYP1A2
SCHEMBL6248907 0.84 GRM2 (0.56) GRM2MEN1TSHRKMT2ACYP1A2
SCHEMBL6246394 0.84 GRM2 (1.00) GRM2MEN1TSHRKMT2ACYSLTR2
Hydrochloric Acid SCHEMBL6245219 0.84 GRM2 (0.98) GRM2MEN1TSHRKMT2ACYSLTR2
SCHEMBL6245759 0.84 CYSLTR1 (0.59) GRM2MEN1TSHRKMT2ACYP1A2
SCHEMBL6247515 0.82 GRM2 (0.53) GRM2MEN1TSHRKMT2ACYP1A2
Bicarbonate SCHEMBL6243604 0.81 GRM2 (0.54) GRM2MEN1TSHRKMT2ACYP1A2
SCHEMBL5329236 0.80 CYSLTR2 (0.68) GRM2MEN1TSHRKMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1556038-A2 ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS Merck & Co., Inc. (US) 2005-07-27 EP disclosed
WO-2004018386-A2 ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS MERCK & CO., INC. (US) 2004-03-04 WO disclosed