SCHEMBL624712

SCHEMBL624712

NCc1cc(-c2cccs2)n[nH]1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.54
CYP2D6 P10635 2/20 0.49
CYP2C9 P11712 2/20 0.49
CYP2C19 P33261 2/20 0.49
CYP2A6 P11509 1/20 0.49
CYP2B6 P20813 1/20 0.49
ADORA3 P0DMS8 1/20 0.46
LTA4H P09960 2/20 0.45
MEN1 O00255 4/20 0.43
KMT2A Q03164 4/20 0.43
MAPT P10636 3/20 0.43
KDM4E B2RXH2 3/20 0.43
ALDH1A1 P00352 2/20 0.43
HPGD P15428 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
NPC1 O15118 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14400727 0.83 SMN1; SMN2 (0.54) SMN1; SMN2CYP2D6CYP2C9CYP2C19ADORA3
SCHEMBL6412460 0.78 HCAR2 (0.50) SMN1; SMN2ADORA3MEN1KMT2AMAPT
SCHEMBL5904032 0.78 COMT (0.54) SMN1; SMN2ADORA3MEN1KMT2AMAPT
SCHEMBL6414035 0.77 SMN1; SMN2 (0.58) SMN1; SMN2CYP2D6CYP2C9CYP2C19ADORA3
SCHEMBL1143192 0.77 SMN1; SMN2 (0.58) SMN1; SMN2CYP2D6CYP2C9CYP2C19ADORA3
SCHEMBL6412673 0.77 SMN1; SMN2 (0.48) SMN1; SMN2ADORA3MEN1KMT2AMAPT
SCHEMBL6418397 0.76 KDM4E (0.47) SMN1; SMN2MEN1KMT2AMAPTKDM4E
SCHEMBL6412005 0.74 SMN1; SMN2 (0.58) SMN1; SMN2CYP2D6CYP2C9CYP2C19ADORA3
SCHEMBL4005632 0.72 CYP2D6 (0.68) CYP2D6CYP2C9CYP2C19CYP2A6CYP2B6
SCHEMBL4923288 0.71 SMN1; SMN2 (0.55) SMN1; SMN2CYP2D6CYP2C9CYP2C19ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012020080-A2 LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY II GRAFFINITY PHARMACEUTICALS GMBH (DE) 2012-02-16 WO disclosed
EP-1989204-A1 PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS Abbott Laboratories (US) 2008-11-12 EP disclosed
WO-2007095628-A1 PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS ABBOTT LABORATORIES (US) 2007-08-23 WO disclosed
EP-1667983-A2 PYRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS Merck & Co., Inc. (US) 2006-06-14 EP disclosed
WO-2005030128-A2 PYRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS MERCK & CO., INC. (US) 2005-04-07 WO disclosed