Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6248454 | 1.00 | — | — | |
| SCHEMBL968386 | 0.96 | — | — | |
| SCHEMBL2490273 | 0.96 | — | — | |
| SCHEMBL968388 | 0.96 | — | — | |
| SCHEMBL14971383 | 0.87 | ALDH1A1 (0.50) | — | |
| SCHEMBL31325376 | 0.87 | ALDH1A1 (0.50) | — | |
| SCHEMBL10960469 | 0.87 | — | — | |
| Bromide SCHEMBL31414018 | 0.80 | — | — | |
| Bromide SCHEMBL28213989 | 0.80 | — | — | |
| Bromide SCHEMBL28299755 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399406-B1 | NOVEL ESTROGEN RECEPTOR LIGANDS AND METHODS I | KAROBIO AB (SE) | 2005-08-10 | — | — | EP | disclosed |
| US-20040127576-A1 | Estrogen receptor modulators | KARO BIO AB (SE) | 2004-07-01 | — | — | US | disclosed |