⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1161082 | 0.79 | ALDH1A1 (0.51) | — | |
| SCHEMBL403393 | 0.74 | — | — | |
| SCHEMBL21317692 | 0.72 | POLB (0.50) | — | |
| SCHEMBL45842 | 0.70 | — | — | |
| SCHEMBL12794077 | 0.70 | — | — | |
| SCHEMBL5657617 | 0.68 | CYP19A1 (0.48) | — | |
| SCHEMBL2362473 | 0.67 | CYP1A2 (0.46) | — | |
| SCHEMBL19318288 | 0.67 | POLB (0.40) | — | |
| SCHEMBL8926510 | 0.67 | EGLN3 (0.44) | — | |
| Hydrochloric Acid SCHEMBL3509917 | 0.67 | EGLN3 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157002-B1 | 1,2,3,4-TETRAHYDRO-1-NAPHTHALENAMINE COMPOUNDS USEFUL IN THERAPY | PFIZER LTD (GB) | 2005-08-10 | — | — | EP | disclosed |
| EP-0835252-B1 | TRIAZOLE ANTIFUNGAL AGENTS | PFIZER RES & DEV (IE) | 2003-07-30 | — | — | EP | disclosed |
| EP-1157002-A1 | 1,2,3,4-TETRAHYDRO-1-NAPHTHALENAMINE COMPOUNDS USEFUL IN THERAPY | Pfizer Limited (GB) | 2001-11-28 | — | — | EP | disclosed |
| US-6200978-B1 | FOR PREVENTING OR TREATING INFLAMMATORY DISEASES SUCH AS ARTHRITIS, PSORIASIS, ASTHMA, OR INFLAMMATORY BOWEL DISEASE, DISORDERS OF RESPIRATORY FUNCTION, GASTROINTESTINAL DISORDERS SUCH AS FUNCTIONAL BOWEL DISEASE, AS ANALGESICS | PFIZER INC. | 2001-03-13 | — | — | US | disclosed |
| WO-2000051972-A1 | 1,2,3,4-TETRAHYDRO-1-NAPHTHALENAMINE COMPOUNDS USEFUL IN THERAPY | PFIZER LIMITED (GB) | 2000-09-08 | — | — | WO | disclosed |
| US-6015825-A | Triazole antifungal agents | PFIZER INC. (US) | 2000-01-18 | — | — | US | disclosed |
| EP-0835252-A1 | TRIAZOLE ANTIFUNGAL AGENTS | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997001552-A1 | TRIAZOLE ANTIFUNGAL AGENTS | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-01-16 | — | — | WO | disclosed |